NEDD8-STON binds TOR1 hexamer and COP9 complex

Stable Identifier
R-HSA-8863721
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NEDD8-STON binds TOR1 hexamer and COP9 complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STON2 protein levels are stabilized by deneddylation, restoring the endocytic uptake of SYT1. Deneddylation is mediated by TOR1A and the CSN4 subunit of the COP9 signalosome, both of which directly bind to STON2 (Granata et al, 2011).

Literature References
PubMed ID Title Journal Year
21102408 CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process

Granata, A, Warner, TT, Schiavo, G, Haucke, V, Koo, SJ

EMBO J. 2011
Participants
Input
Output
Participates
as an event of
Orthologous Events
NEDD8-STON binds TOR1 hexamer and COP9 complex (Bos taurus)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Caenorhabditis elegans)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Canis familiaris)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Drosophila melanogaster)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Mus musculus)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)
NEDD8-STON binds TOR1 hexamer and COP9 complex (Xenopus tropicalis)
Authored
Rothfels, K  (2016-05-11)
Reviewed
Antonescu, CN  (2016-05-10)
Created
Rothfels, K  (2016-03-10)
Cite Us!