Reactome | AGFG1 binds VAMP7

AGFG1 binds VAMP7

Stable Identifier

R-HSA-8863718

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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AGFG1, also known as HRB (HIV-1 Rev-binding), is a clathrin adaptor and ArfGAP that interacts with the R-SNARE VAMP7 to mediate its endocytosis from the plasma membrane (Pryor et al, 2008; Chaineau et al, 2008). AGFG1 also interacts with a number of other endocytic proteins such as EPS15, EPS15R, FCHos and ITSNs (Doria et al, 1999; Salcini et al, 1997; Schmid et al, 2006; Umasankar et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
18819912	Role of HRB in clathrin-dependent endocytosis Chaineau, M, Danglot, L, Proux-Gillardeaux, V, Galli, T	J. Biol. Chem.	2008
22484487	Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning Umasankar, PK, Sanker, S, Thieman, JR, Chakraborty, S, Wendland, B, Tsang, M, Traub, LM	Nat. Cell Biol.	2012
9303539	Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module Salcini, AE, Confalonieri, S, Doria, M, Santolini, E, Tassi, E, Minenkova, O, Cesareni, G, Pelicci, PG, Di Fiore, PP	Genes Dev	1997
10613896	The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport Doria, M, Salcini, AE, Colombo, E, Parslow, TG, Pelicci, PG, Di Fiore, PP	J. Cell Biol.	1999
18775314	Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb Pryor, PR, Jackson, L, Gray, SR, Edeling, MA, Thompson, A, Sanderson, CM, Evans, PR, Owen, DJ, Luzio, JP	Cell	2008
16903783	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly Schmid, EM, Ford, MG, Burtey, A, Praefcke, GJ, Peak-Chew, SY, Mills, IG, Benmerah, A, McMahon, HT	PLoS Biol.	2006