CDC25C binds YWHAE (14-3-3-epsilon)

Stable Identifier
R-HSA-8863674
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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CDC25C binds YWHAE (14-3-3-epsilon)
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Binding of CDC25C to 14-3-3-epsilon (YWHAE), which promotes retention of CDC25C in the cytosol, is inhibited by CDK5-mediated phosphorylation of CDC25C (Chang et al. 2012).

Literature References
PubMed ID Title Journal Year
22899714 Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

Chang, KH, Vincent, F, Shah, K

J. Cell. Sci. 2012
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Output
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as an event of
This event is regulated
Negatively by
Regulator
CDK5:p25 [cytosol] (Homo sapiens)
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-03-09)
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