ASICs bind STOML3, (STOM)

Stable Identifier
R-HSA-8863494
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Stomatin (STOM) and Stomatin-like protein 3 (STOML3) are accessory proteins for the ASIC channels (Zeng et al. 2014). STOML3 and stomatin are expressed by primary sensory neurons of the dorsal root ganglia (DRG) (Mannsfeldt et al. 1999, Wetzel et al. 2007) and regulate mechanoreceptor sensitivity in mice (Wetzel et al. 2007, Martinez-Saldago et al. 2007). STOML3 and to a lesser extent STOM can modulate the gating of ASICs (Price et al. 2004, Wetzel et al. 2007). STOML3 can bind ASIC1a, 1b, 2a, 2b, 3 and 4 (Lapatsina et al. 2012) . The function of STOML3 may be to prime the transduction complex for insertion into the plasma membrane (Lapatsina et al. 2012). Alternatively, STOML3 may control membrane mechanics by binding cholesterol to tune the sensitivity of mechano-gated channels(Qi et al. 2015).

Literature References
PubMed ID Title Journal Year
22773952 Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons

Lapatsina, L, Jira, JA, Smith, ES, Poole, K, Kozlenkov, A, Bilbao, D, Lewin, GR, Heppenstall, PA

Open Biol 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!