Stomatin (STOM) and Stomatin-like protein 3 (STOML3) are accessory proteins for the ASIC channels (Zeng et al. 2014). STOML3 and stomatin are expressed by primary sensory neurons of the dorsal root ganglia (DRG) (Mannsfeldt et al. 1999, Wetzel et al. 2007) and regulate mechanoreceptor sensitivity in mice (Wetzel et al. 2007, Martinez-Saldago et al. 2007). STOML3 and to a lesser extent STOM can modulate the gating of ASICs (Price et al. 2004, Wetzel et al. 2007). STOML3 can bind ASIC1a, 1b, 2a, 2b, 3 and 4 (Lapatsina et al. 2012) . The function of STOML3 may be to prime the transduction complex for insertion into the plasma membrane (Lapatsina et al. 2012). Alternatively, STOML3 may control membrane mechanics by binding cholesterol to tune the sensitivity of mechano-gated channels(Qi et al. 2015).