Reactome | DAB2 binds LRP2

DAB2 binds LRP2

Stable Identifier

R-HSA-8863472

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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DAB2 interacts by coimmunoprecipitation with the LDL receptor family protein LRP2 (also known as Megalin) through the third intracellular NPxY motif of LRP2 (Gallagher et al, 2004; Oleinikov et al, 2000). While the functional significance of this interaction remains to be elucidated, Dab2-/- mice show phenotypes consistent with reduced LRP2 endocytosis, suggesting that the interaction may help to sort LRP2 into clathrin-coated pits (Morris et al, 2002; Mishra et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
10769163	Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin Oleinikov, AV, Zhao, J, Makker, SP	Biochem. J.	2000
11927540	Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport Morris, SM, Tallquist, MD, Rock, CO, Cooper, JA	EMBO J.	2002
15134832	The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin Gallagher, H, Oleinikov, AV, Fenske, C, Newman, DJ	Biochimie	2004
12234931	Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor Mishra, SK, Keyel, PA, Hawryluk, MJ, Agostinelli, NR, Watkins, SC, Traub, LM	EMBO J.	2002