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CRBN [cytosol]
Stable Identifier
R-HSA-8863300
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein cereblon, CRBN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
CRBN binds IMiDs (Homo sapiens)
CRBN [cytosol] (Homo sapiens)
CRBN:IMiDs [cytosol] (Homo sapiens)
CRBN [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
26188093
Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction
Yamada, H
,
Sawamura, N
,
Matsumoto, K
,
Asahi, T
,
Wakabayashi, S
Biochem. Biophys. Res. Commun.
2015
External Reference Information
External Reference
UniProt:Q96SW2 CRBN
Gene Names
CRBN, AD-006
Chain
chain:1-442
Reference Genes
COSMIC (genes):CRBN CRBN
dbSNP Gene:51185 CRBN
ENSEMBL:ENSG00000113851 CRBN
Participates
as a component of
CRBN:IMiDs [cytosol] (Homo sapiens)
as an input of
CRBN binds IMiDs (Homo sapiens)
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.723
4
UniProt:Q9P286 PAK5
2
PAK5 [cytosol]
(R-HSA-428459)
PAK7 [plasma membrane]
(R-HSA-211555)
0.666
4
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.648
4
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.648
6
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.641
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:Q93062 RBPMS
0.556
3
UniProt:Q8IVT2 MISP
0.556
3
UniProt:Q96A83-2 Q96A832
0.556
3
UniProt:O14901 KLF11
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.528
2
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.528
2
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.527
5
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