CDK5 binds p25

Stable Identifier
R-HSA-8863013
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

p25 has a 5-10 fold longer half-life compared to p35 and lacks the membrane anchoring signal, which results in its constitutive activation and mislocalization of the CDK5:p25 complex to the cytoplasm and the nucleus (Patrick et al. 1999). As CDK5 deregulation triggers nuclear envelope dispersion (Chang et al. 2011), with timing being uncertain, all phosphorylation events catalyzed by the CDK5:p25 complex are shown to occur in the cytosol.

Literature References
PubMed ID Title Journal Year
10604467 Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Patrick, GN, Zukerberg, L, Nikolic, M, de la Monte, S, Dikkes, P, Tsai, LH

Nature 1999
Participants
Participant Of
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Created