Reactome | STON1 [cytosol]

STON1 [cytosol]

Stable Identifier

R-HSA-8862854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Stonin-1, STON1_HUMAN

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - COP9 and TOR1 deneddylate STON2 (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - STON2 binds SYT proteins (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - STON2 is neddylated (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [plasma membrane] (Homo sapiens)
        
        STON2,1 [cytosol] (Homo sapiens)
        
        STON1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6Q2 STON1

Gene Names

STON1, SALF, SBLF, STN1

Chain

chain:1-735

Reference Genes

BioGPS Gene:11037 STON1

BioGPS Gene:286749 STON1

COSMIC (genes):STON1 STON1

CTD Gene:11037 STON1

CTD Gene:286749 STON1

dbSNP Gene:11037 STON1

dbSNP Gene:286749 STON1

ENSEMBL:ENSG00000243244 STON1

HGNC:17003 STON1

KEGG Gene (Homo sapiens):11037 STON1

KEGG Gene (Homo sapiens):286749 STON1

Monarch:11037 STON1

Monarch:286749 STON1

NCBI Gene:11037 STON1

NCBI Gene:286749 STON1

OMIM:605357 STON1

UCSC:Q9Y6Q2 STON1

Reference Transcript

Other Identifiers

0002510121

0006590148

11037

11739699_at

11739700_a_at

213413_at

231795_at

2481380

2481382

2481384

2481405

2481406

2481407

2481408

2481409

2481412

2481413

2481414

2481415

2481416

34675_at

46915_at

A_14_P101833

A_23_P302005

GO:0003674

GO:0005575

GO:0005622

GO:0005737

GO:0006810

GO:0006897

GO:0008021

GO:0008150

GO:0016020

GO:0016192

GO:0030100

GO:0030136

GO:0030674

GO:0031410

GO:0035615

GO:0043226

GO:0043231

GO:0048488

HMNXSV003031610

Hs.23437.0.S1_3p_at

Hs.54961.1.S2_3p_at

ILMN_1656409

ILMN_1668592

PH_hs_0041007

Participates

as a candidate of

STON2,1 [cytosol] (Homo sapiens)

Other forms of this molecule

NEDD8-STON1 [cytosol]

Inferred To

Homologues of STON1 [cytosol] (Plasmodium falciparum)

Homologues of STON1 [cytosol] (Saccharomyces cerevisiae)

Ston1 [cytosol] (Mus musculus)

Ston1 [cytosol] (Rattus norvegicus)

STON1 [cytosol] (Bos taurus)

STON1 [cytosol] (Gallus gallus)

STON1 [cytosol] (Plasmodium falciparum)

APM2 [cytosol] (Saccharomyces cerevisiae)

ston2 [cytosol] (Danio rerio)

stnB [cytosol] (Drosophila melanogaster)

apm2 [cytosol] (Dictyostelium discoideum)

ston1 [cytosol] (Xenopus tropicalis)

APM4 [cytosol] (Saccharomyces cerevisiae)

unc-41 [cytosol] (Caenorhabditis elegans)

apm4 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001185522.1, NP_001185523.1, NP_001185524.1, NP_006864.2

OpenTargets

ENSG00000243244

HPA

ENSG00000243244-STON1

GeneCards

Q9Y6Q2

Ensembl

ENST00000649748, ENSP00000385273, ENSG00000243244, ENSP00000497745, ENSP00000384615, ENST00000404752, ENST00000406226

PRO

Q9Y6Q2

Pharos - Targets

Q9Y6Q2

GlyGen

Q9Y6Q2

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