Reactome | CCR2, CCR3 bind CCL13

CCR2, CCR3 bind CCL13

Stable Identifier

R-HSA-8862733

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        CCR2, CCR3 bind CCL13 (Homo sapiens)

General

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C-C motif chemokine 13 (MCP-4, CCL13) is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. It signals through the CCR2B and CCR3 receptors.

Literature References

PubMed ID	Title	Journal	Year
12554737	A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6 Schwartz, TW, Lüttichau, HR, Moser, C, Gerstoft, J, Jensen, PØ, Clark-Lewis, I	J. Biol. Chem.	2003
9276730	High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines Ponath, PD, Baggiolini, M, Dahinden, CA, Rao, P, Rhis, S, Ochensberger, B, Uguccioni, M, LaRosa, GJ, Loetscher, P, Mackay, CR	J. Clin. Invest.	1997