CMKLR1 [plasma membrane]

Stable Identifier
R-HSA-8862709
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Chemokine-like receptor 1, CML1_HUMAN, ChemR23, DEZ
Locations in the PathwayBrowser
General

Chemokine-like receptor 1 (CMKLR1, ERV1, CHEMR23, DEZ) is activated by the essentil fatty acid-derived, pro-inflammation resolving ligand resolvin E1 (RvE1), which is the result of sequential enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA) by aspirin-modified cyclooxygenase or cytochrome P450 and 5-lipoxygenase. RvE1 is produced in both 18(S)- and 18(R)-stereoisomeric forms (Arita et al. 2005, 2007).

CMKLR1 is also reported to be a receptor for chemerin (Wittamer et al. 2003) and RvE1 is reported to be a partial agonist for Leukotriene B4 receptor 1 (LTB4R, BLT1, CMKRL1) (Arita et al. 2007).

CMKLR1 signals via the Akt/rS6/mTOR pathway (Ohira et al. 2010). This RvE1 mediated signaling influences is believed to actively promote the resolution of inflammation (Freire et al. 2017).

External Reference Information
External Reference
Gene Names
CMKLR1, CHEMR23, DEZ
Chain
chain:1-373
Other Identifiers
0003610121
11723910_a_at
11741424_a_at
11742192_a_at
11752271_a_at
1240
16769690
207652_s_at
210659_at
229121_at
3470192
3470194
3470195
3470196
3470197
3470198
3470199
3470205
3470210
3470213
36390_at
59616_at
7966089
90844_at
A_23_P105461
A_23_P105465
A_24_P766716
GE61514
GE825680
GO:0001501
GO:0002376
GO:0002430
GO:0003674
GO:0004875
GO:0004930
GO:0004950
GO:0005515
GO:0005575
GO:0005886
GO:0005887
GO:0006935
GO:0006950
GO:0006954
GO:0006955
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0008150
GO:0009058
GO:0010759
GO:0016020
GO:0016021
GO:0030154
GO:0032088
GO:0032695
GO:0034641
GO:0038023
GO:0040011
GO:0042592
GO:0045600
GO:0048856
GO:0048870
GO:0050848
GO:0070098
GO:0120162
Hs.197143.0.A1_3p_at
ILMN_1673030
ILMN_1913060
PH_hs_0009721
PH_hs_0011636
TC12001933.hg
TC12003071.hg
U79526_at
g1732342_3p_at
g1732342_3p_x_at
g4758013_3p_a_at
Participant Of
Inferred To
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