CMKLR1 [plasma membrane]

Stable Identifier
R-HSA-8862709
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Chemokine-like receptor 1, CML1_HUMAN, ChemR23, DEZ
Locations in the PathwayBrowser
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General
Chemokine-like receptor 1 (CMKLR1, ERV1, CHEMR23, DEZ) is activated by the essentil fatty acid-derived, pro-inflammation resolving ligand resolvin E1 (RvE1), which is the result of sequential enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA) by aspirin-modified cyclooxygenase or cytochrome P450 and 5-lipoxygenase. RvE1 is produced in both 18(S)- and 18(R)-stereoisomeric forms (Arita et al. 2005, 2007).

CMKLR1 is also reported to be a receptor for chemerin (Wittamer et al. 2003) and RvE1 is reported to be a partial agonist for Leukotriene B4 receptor 1 (LTB4R, BLT1, CMKRL1) (Arita et al. 2007).

CMKLR1 signals via the Akt/rS6/mTOR pathway (Ohira et al. 2010). This RvE1 mediated signaling influences is believed to actively promote the resolution of inflammation (Freire et al. 2017).
External Reference Information
External Reference
UniProt:Q99788 CMKLR1
Gene Names
CMKLR1, CHEMR23, DEZ
Chain
chain:1-373
Reference Genes
BioGPS Gene:1240 CMKLR1
COSMIC (genes):CMKLR1 CMKLR1
CTD Gene:1240 CMKLR1
dbSNP Gene:1240 CMKLR1
ENSEMBL:ENSG00000174600 CMKLR1
ENSEMBL_homo_sapiens_GENE:ENSG00000174600.14 CMKLR1
HGNC:2121 CMKLR1
KEGG Gene (Homo sapiens):1240 CMKLR1
Monarch:1240 CMKLR1
NCBI Gene:1240 CMKLR1
OMIM:602351 CMKLR1
UCSC:Q99788 CMKLR1
Reference Transcript
Other Identifiers
11723910_a_at
11741424_a_at
11742192_a_at
11752271_a_at
1240
16769690
207652_PM_s_at
207652_s_at
210659_at
229121_PM_at
229121_at
3470192
3470194
3470195
3470196
3470197
3470198
3470199
3470205
3470210
3470213
36390_at
59616_at
7966089
90844_at
A_23_P105461
A_23_P105465
A_24_P766716
GE61514
GE825680
GO:0001501
GO:0002376
GO:0002430
GO:0004875
GO:0004930
GO:0004950
GO:0005515
GO:0005886
GO:0006351
GO:0006355
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0010759
GO:0016020
GO:0023052
GO:0030154
GO:0032088
GO:0032695
GO:0038023
GO:0045600
GO:0048856
GO:0048870
GO:0050848
GO:0060089
GO:0070098
GO:0097003
GO:0097004
GO:0120162
HMNXSV003004422
Hs.197143.0.A1_3p_at
ILMN_1673030
ILMN_1913060
PH_hs_0009721
PH_hs_0011636
TC12001933.hg
TC12003071.hg
U79526_at
g1732342_3p_at
g1732342_3p_x_at
g4758013_3p_a_at
Participates
as a component of
as an input of
Inferred To
Cmklr1 [plasma membrane] (Mus musculus)
Cmklr1 [plasma membrane] (Rattus norvegicus)
cmklr1 [plasma membrane] (Xenopus tropicalis)
CMLKR1 [plasma membrane] (Bos taurus)
CMLKR1 [plasma membrane] (Sus scrofa)
CMKLR1 [plasma membrane] (Canis familiaris)
CMKLR1 [plasma membrane] (Gallus gallus)
Cross References
RefSeq
Guide to Pharmacology - Targets
79
OpenTargets
HPA
GeneCards
Ensembl
ZINC target
PRO
Pharos - Targets
PDB
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