Chemokine-like receptor 1 (CMKLR1, ERV1, CHEMR23, DEZ) is activated by the essentil fatty acid-derived, pro-inflammation resolving ligand resolvin E1 (RvE1), which is the result of sequential enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA) by aspirin-modified cyclooxygenase or cytochrome P450 and 5-lipoxygenase. RvE1 is produced in both 18(S)- and 18(R)-stereoisomeric forms (Arita et al. 2005, 2007).
CMKLR1 is also reported to be a receptor for chemerin (Wittamer et al. 2003) and RvE1 is reported to be a partial agonist for Leukotriene B4 receptor 1 (LTB4R, BLT1, CMKRL1) (Arita et al. 2007).
CMKLR1 signals via the Akt/rS6/mTOR pathway (Ohira et al. 2010). This RvE1 mediated signaling influences is believed to actively promote the resolution of inflammation (Freire et al. 2017).