CMKLR1

Stable Identifier
R-HSA-8862709
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Chemokine-like receptor 1, CML1_HUMAN, ChemR23, DEZ
Locations in the PathwayBrowser
Summation

Chemokine-like receptor 1 (CMKLR1, ERV1, CHEMR23, DEZ) is activated by the essentil fatty acid-derived, pro-inflammation resolving ligand resolvin E1 (RvE1), which is the result of sequential enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA) by aspirin-modified cyclooxygenase or cytochrome P450 and 5-lipoxygenase. RvE1 is produced in both 18(S)- and 18(R)-stereoisomeric forms (Arita et al. 2005, 2007).

CMKLR1 is also reported to be a receptor for chemerin (Wittamer et al. 2003) and RvE1 is reported to be a partial agonist for Leukotriene B4 receptor 1 (LTB4R, BLT1, CMKRL1) (Arita et al. 2007).

CMKLR1 signals via the Akt/rS6/mTOR pathway (Ohira et al. 2010). This RvE1 mediated signaling influences is believed to actively promote the resolution of inflammation (Freire et al. 2017).

External Reference Information
External Reference
Gene Names
CMKLR1, CHEMR23, DEZ
Chain
chain:1-373
Other Identifiers
0003610121
11723910_a_at
11741424_a_at
11742192_a_at
11752271_a_at
1240
16769690
207652_s_at
210659_at
229121_at
3470192
3470194
3470195
3470196
3470197
3470198
3470199
3470205
3470210
3470213
36390_at
47865
59616_at
7966089
90844_at
A_23_P105461
A_23_P105465
A_24_P766716
AAC51258
AAC51259
AAI06928
AAI06929
AAR90850
AAV38363
AAV38364
AB065871
AC009729
AC063957
AK291800
AY497547
BAC06089
BAF84489
BC106927
BC106928
BT019556
BT019557
CAA75112
CCDS41829
CCDS44965
CH471054
CMKLR1
CMKLR1-201
CMKLR1-202
CMKLR1-204
CMKLR1-206
EAW97810
EAW97811
ENSG00000174600
ENSP00000311733
ENSP00000401293
ENSP00000447579
ENSP00000449716
ENST00000312143
ENST00000412676
ENST00000550402
ENST00000552995
EntrezGene:1240
F8VSC8
F8VYN7
g1732342_3p_at
g1732342_3p_x_at
g4758013_3p_a_at
GE61514
GE825680
GO:0001501
GO:0002376
GO:0003674
GO:0004871
GO:0004930
GO:0004950
GO:0005515
GO:0005575
GO:0005623
GO:0005886
GO:0005887
GO:0006935
GO:0006955
GO:0007165
GO:0007186
GO:0008150
GO:0009058
GO:0010759
GO:0016020
GO:0016021
GO:0030154
GO:0032088
GO:0032695
GO:0034641
GO:0038023
GO:0040011
GO:0045600
GO:0048856
GO:0048870
GO:0050848
GO:0070098
HGNC:2121
HPA047865
Hs.197143.0.A1_3p_at
ILMN_1673030
ILMN_1913060
IPR000276
IPR002258
IPR017452
MIM:602351
NM_001142343
NM_001142344
NM_001142345
NM_004072
NP_001135815
NP_001135816
NP_001135817
NP_004063
PF00001
PH_hs_0009721
PH_hs_0011636
PR00237
PR01126
TC12001933.hg
TC12003071.hg
U79526
U79526_at
U79527
uc001tmv.4
uc001tmw.4
uc009zuv.3
uc009zuw.3
UPI00000015B3
UPI0000127BD4
XM_017018820
XP_016874309
Y14838
Participant Of
Inferred To
Cross References
GeneCards
ZINC target
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