CMKLR1 binds Resolvin E1

Stable Identifier
R-HSA-8862700
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Chemokine-like receptor 1 (CMKLR1, ERV1, CHEMR23, DEZ) is activated by the essentil fatty acid-derived, pro-inflammation resolving ligand resolvin E1 (RvE1), which is the result of sequential enzymatic conversion of the omega-3 fatty acid eicosapentaenoic acid (EPA) by aspirin-modified cyclooxygenase or cytochrome P450 and 5-lipoxygenase. RvE1 is produced in both 18(S)- and 18(R)-stereoisomeric forms (Arita et al. 2005, 2007).

CMKLR1 is also reported to be a receptor for chemerin (Wittamer et al. 2003) and RvE1 is reported to be a partial agonist for Leukotriene B4 receptor 1 (LTB4R, BLT1, CMKRL1) (Arita et al. 2007).

CMKLR1 signals via the Akt/rS6/mTOR pathway (Ohira et al. 2010). This RvE1 mediated signaling influences is believed to actively promote the resolution of inflammation (Freire et al. 2017).

Literature References
PubMed ID Title Journal Year
17339491 Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation

Arita, M, Ohira, T, Sun, YP, Elangovan, S, Chiang, N, Serhan, CN

J. Immunol. 2007
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