Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ORAI2 [plasma membrane]
Stable Identifier
R-HSA-8862647
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Protein orai-2, ORAI2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI2 dimer [plasma membrane] (Homo sapiens)
ORAI2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96SN7 ORAI2
Gene Names
ORAI2, C7orf19, CBCIP2, TMEM142B, PP1729
Chain
chain:1-254
Reference Genes
BioGPS Gene:80228 ORAI2
COSMIC (genes):ORAI2 ORAI2
CTD Gene:80228 ORAI2
dbSNP Gene:80228 ORAI2
ENSEMBL:ENSG00000160991 ORAI2
HGNC:21667 ORAI2
KEGG:hsa:80228 ORAI2
Monarch:80228 ORAI2
NCBI Gene:80228 ORAI2
OMIM:610929 ORAI2
UCSC:Q96SN7 ORAI2
Reference Transcript
RefSeq:NM_001271818.2 ORAI2
RefSeq:NM_032831.4 ORAI2
RefSeq:NM_001126340.3 ORAI2
Other Identifiers
11732231_a_at
11732232_x_at
11748908_a_at
11755076_x_at
1558426_3p_x_at
1558426_PM_x_at
1558426_x_at
17049814
217529_PM_at
217529_at
218811_PM_at
218811_at
218812_3p_s_at
218812_PM_s_at
218812_s_at
231406_PM_at
231406_at
2447978
2495543
3016769
3016772
3016773
3016774
3016776
3016777
3016778
3016779
3016780
3016781
3016782
3016783
3016784
3016785
3016786
3016787
3016788
3016790
3016792
3016793
3016794
3016795
3016796
3016797
3016798
3016799
40495_at
77619_at
80228
81293_at
8135172
89996_at
91977_s_at
91978_r_at
A_14_P101128
A_14_P131873
A_23_P70915
A_24_P329353
A_24_P337867
GE62643
GE757369
GO:0002115
GO:0005215
GO:0005262
GO:0005515
GO:0005886
GO:0015279
GO:0016020
GO:0055085
GO:0070588
HMNXSV003041163
HMNXSV003042443
Hs.129568.0.A1_3p_at
Hs.204169.0.A1_3p_at
Hs.289053.0.S1_3p_at
PH_hs_0015028
PH_hs_0033460
PH_hs_0039360
TC07000659.hg
g13376752_3p_a_at
g13376752_3p_x_at
Participates
as a component of
ORAI2 dimer [plasma membrane] (Homo sapiens)
Cross References
RefSeq
NP_001258747.1
,
NP_116220.1
,
NP_001119812.1
Guide to Pharmacology - Targets
2965
ENSEMBL
ENSP00000418464
,
ENSP00000385489
,
ENST00000473939
,
ENST00000356387
,
ENST00000478730
,
ENSG00000160991
,
ENST00000495936
,
ENSP00000420178
,
ENSP00000478113
,
ENSP00000418140
,
ENSP00000417928
,
ENST00000611770
,
ENSP00000348752
,
ENST00000403646
,
ENST00000498661
OpenTargets
ENSG00000160991
GeneCards
ORAI2
HPA
ENSG00000160991-ORAI2
PRO
Q96SN7
Pharos - Targets
Q96SN7
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text