Reactome | HSD17B13 binds lipid droplets

HSD17B13 binds lipid droplets

Stable Identifier

R-HSA-8862380

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lipid droplet

ReviewStatus

5/5

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The short-chain dehydrogenases/reductases (SDR) family is a large family of NAD- or NADP-dependent oxidoreductase enzymes. 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) is a recently-discovered member of this family whose physiological function is unknown (Liu et al. 2007). It has, however, been found to associate with lipid droplets and is significantly upregulated in patients with nonalcoholic fatty liver disease (NAFLD) which is characterised by an accumulation of lipid droplets in the liver. In a murine model of fatty liver and diabetes, mice with fatty livers show upregulated expression of HSD17B13, suggesting a pathogenic role for HSD17B13 in NAFLD development (Su et al. 2014). Its role in lipid droplet function under normal physiological conditions is unknown.

Literature References

PubMed ID	Title	Journal	Year
25028495	Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease Su, W, Wang, Y, Jia, X, Wu, W, Li, L, Tian, X, Li, S, Wang, C, Xu, H, Cao, J, Han, Q, Xu, S, Chen, Y, Zhong, Y, Zhang, X, Liu, P, Gustafsson, JA, Guan, Y	Proc. Natl. Acad. Sci. U.S.A.	2014
17311113	Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9 Liu, S, Huang, C, Li, D, Ren, W, Zhang, H, Qi, M, Li, X, Yu, L	Acta Biochim. Pol.	2007