HSD17B13 binds lipid droplets

Stable Identifier
R-HSA-8862380
Type
Reaction [binding]
Species
Homo sapiens
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The short-chain dehydrogenases/reductases (SDR) family is a large family of NAD- or NADP-dependent oxidoreductase enzymes. 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) is a recently-discovered member of this family whose physiological function is unknown (Liu et al. 2007). It has, however, been found to associate with lipid droplets and is significantly upregulated in patients with nonalcoholic fatty liver disease (NAFLD) which is characterised by an accumulation of lipid droplets in the liver. In a murine model of fatty liver and diabetes, mice with fatty livers show upregulated expression of HSD17B13, suggesting a pathogenic role for HSD17B13 in NAFLD development (Su et al. 2014).

Literature References
PubMed ID Title Journal Year
17311113 Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9

Liu, S, Huang, C, Li, D, Ren, W, Zhang, H, Qi, M, Li, X, Yu, L

Acta Biochim. Pol. 2007
25028495 Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

Su, W, Wang, Y, Jia, X, Wu, W, Li, L, Tian, X, Li, S, Wang, C, Xu, H, Cao, J, Han, Q, Xu, S, Chen, Y, Zhong, Y, Zhang, X, Liu, P, Gustafsson, JA, Guan, Y

Proc. Natl. Acad. Sci. U.S.A. 2014
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