LYZ binds bacterial peptidoglycan

Stable Identifier
R-HSA-8862300
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human lysozyme (LYZ), also known as 1,4-beta-N-acetylmuramidase C, is found in human secretions such as tears, milk, mucus and saliva (Surna A et al. 2009; Minami J et al. 2015; Sahin O et al. 2016; Masschalck B & Michiels CW. 2003). LYZ functions primarily as a bacteriolytic agent by catalyzing hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in the bacterial cell wall peptidoglycan (Schindler M et al. 1977; Surna A et al. 2009). Nonenzymatic bactericidal activity of LYZ has been documented as well and is generally associated with the cationic properties of LYZ (Ito Y et al. 1997; Nash JA et al. 2006). LYZ acts against both Gram-positive and Gram-negative bacteria such as Peptostreptococcus micros, Eubacterium nodatum, Eikenella corrodens, Fusobacterium periodontium and Campylobacter rectus (Laible & Germaine 1985, Surna A et al. 2009; Tenovuo J 2002).

Literature References
PubMed ID Title Journal Year
19179970 Lysozyme and microbiota in relation to gingivitis and periodontitis

Surna, A, Kubilius, R, Sakalauskiene, J, Vitkauskiene, A, Jonaitis, J, Saferis, V, Gleiznys, A

Med. Sci. Monit. 2009
13816 Mechanism of lysozyme catalysis: role of ground-state strain in subsite D in hen egg-white and human lysozymes

Schindler, M, Assaf, Y, Sharon, N, Chipman, DM

Biochemistry 1977
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created