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TMPRSS6 [plasma membrane]
Stable Identifier
R-HSA-8862100
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Transmembrane protease serine 6, TMPS6_HUMAN, Matriptase-2
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type I degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
Collagen type II degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
Collagen type III degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
DCN (decorin) degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
Elastin degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
Fibrillin-1 degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
Laminin-322 degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
Laminin-511 degradation by MMP14 (Homo sapiens)
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
TMPRSS6 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IU80 TMPRSS6
Gene Names
TMPRSS6, UNQ354/PRO618
Chain
chain:1-811
Reference Genes
BioGPS Gene:164656 TMPRSS6
COSMIC (genes):TMPRSS6 TMPRSS6
CTD Gene:164656 TMPRSS6
dbSNP Gene:164656 TMPRSS6
ENSEMBL:ENSG00000187045 TMPRSS6
HGNC:16517 TMPRSS6
KEGG:hsa:164656 TMPRSS6
Monarch:164656 TMPRSS6
NCBI Gene:164656 TMPRSS6
OMIM:609862 TMPRSS6
UCSC:Q8IU80 TMPRSS6
Reference Transcript
RefSeq:NM_001289001.1 TMPRSS6
RefSeq:NM_153609.3 TMPRSS6
RefSeq:NM_001289000.1 TMPRSS6
Other Identifiers
11731388_a_at
11752647_a_at
164656
16934681
214955_PM_at
214955_at
232941_PM_at
232941_at
234367_PM_x_at
234367_x_at
34067_at
3959954
3959955
3959956
3959957
3959959
3959961
3959962
3959963
3959964
3959965
3959966
3959967
3959968
3959969
3959970
3959971
3959972
3959973
3959974
3959975
3959976
3959977
3959978
3959979
3959980
3959982
3959983
8075865
A_23_P211493
A_23_P313588
A_24_P130691
GE531509
GE79665
GO:0000122
GO:0003824
GO:0004222
GO:0004252
GO:0005515
GO:0005615
GO:0005886
GO:0006355
GO:0006508
GO:0006879
GO:0008236
GO:0016020
GO:0016787
GO:0022617
GO:0030198
GO:0030509
GO:0030514
GO:0030574
GO:0033619
GO:0045892
GO:0045944
GO:0060586
GO:0097264
GO:0140096
HMNXSV003049602
HMNXSV003053199
Hs.194750.0.S1_3p_at
Hs.251417.0.S1_3p_at
Hs.272271.0.S1_3p_at
ILMN_1725014
TC22000720.hg
Participates
as a member of
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Inferred To
TMPRSS6 [plasma membrane]
(Bos taurus)
TMPRSS6 [plasma membrane]
(Canis familiaris)
TMPRSS6 [plasma membrane]
(Gallus gallus)
TMPRSS6 [plasma membrane]
(Sus scrofa)
Tmprss6 [plasma membrane]
(Mus musculus)
Tmprss6 [plasma membrane]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2422
ENSEMBL
ENST00000676104
,
ENSP00000385453
,
ENSP00000501573
,
ENST00000381792
,
ENST00000406725
,
ENSP00000371211
,
ENST00000406856
,
ENSP00000334962
,
ENST00000346753
,
ENSP00000384964
,
ENSG00000187045
OpenTargets
ENSG00000187045
ZINC - Substances
TMPS6_HUMAN
ZINC target
Q8IU80
PRO
Q8IU80
GlyGen
Q8IU80
GeneCards
TMPRSS6
HPA
ENSG00000187045-TMPRSS6
Pharos - Targets
Q8IU80
Orphanet
TMPRSS6
ZINC - Predictions - Purchasable
TMPS6_HUMAN
HMDB Protein
HMDBP08697
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