PILRA,PILRB bind CD99

Stable Identifier
R-HSA-8862084
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PILRA,PILRB bind CD99
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The paired immunoglobulin-like type 2 receptors (PILR) comprise the inhibitory receptor PILRA and the activating receptor PILRB (Shiratori et al. 2004). The inhibitory PILRA is mainly expressed on macrophages, dendritic cells and granulocytes, whereas the activating PILRB is mainly on activated NK cells. Both recognize mouse CD99 as a ligand, but the binding affinity of PILRB is much lower (Tabata et al. 2008). Mouse NK cells expressing PILRB mediate cytotoxicity against CD99-positive target cells, suggesting that this receptor may be involved in NK cell recognition (Shiratori et al. 2004).
Literature References
PubMed ID Title Journal Year
18234675 Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors

Tabata, S, Kuroki, K, Wang, J, Kajikawa, M, Shiratori, I, Kohda, D, Arase, H, Maenaka, K

J. Biol. Chem. 2008
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Orthologous Events
PILRA,PILRB bind CD99 (Bos taurus)
PILRA,PILRB bind CD99 (Canis familiaris)
PILRA,PILRB bind CD99 (Rattus norvegicus)
PILRA,PILRB bind CD99 (Sus scrofa)
Authored
Jupe, S  (2016-02-25)
Reviewed
Zarrin, AA  (2017-01-30)
Created
Jupe, S  (2016-02-25)
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