Reactome | HSD17B13 [cytosol]

HSD17B13 [cytosol]

Stable Identifier

R-HSA-8862029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

17-beta-hydroxysteroid dehydrogenase 13, DHB13_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q53HI1 UNC50

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External Reference Information

External Reference

UniProt:Q7Z5P4 HSD17B13

Gene Names

HSD17B13, SCDR9, SDR16C3, HMFN0376, UNQ497/PRO1014

Chain

signal peptide:1-19, chain:20-300

Reference Genes

BioGPS Gene:345275 HSD17B13

COSMIC (genes):HSD17B13 HSD17B13

CTD Gene:345275 HSD17B13

dbSNP Gene:345275 HSD17B13

ENSEMBL:ENSG00000170509 HSD17B13

ENSEMBL_homo_sapiens_GENE:ENSG00000170509.12 HSD17B13

HGNC:18685 HSD17B13

KEGG Gene (Homo sapiens):345275 HSD17B13

Monarch:345275 HSD17B13

NCBI Gene:345275 HSD17B13

OMIM:612127 HSD17B13

UCSC:Q7Z5P4 HSD17B13

Reference Transcript

Other Identifiers

11732540_a_at

11732541_a_at

11738831_x_at

16977810

2777045

2777046

2777047

2777048

2777050

2777051

2777052

2777053

2777055

2777058

2777060

2777061

345275

8101637

A_24_P362969

GE517709

GO:0003674

GO:0003824

GO:0004303

GO:0004745

GO:0005515

GO:0005737

GO:0005783

GO:0005811

GO:0005829

GO:0006629

GO:0016229

GO:0016491

GO:0016616

GO:0043226

GO:0046889

HMNXSV003026120

ILMN_1683844

ILMN_2204576

PH_hs_0023472

TC04002944.hg

p33560

Participates

as a component of

HSD17B13:lipid droplet [lipid droplet] (Homo sapiens)

as an input of

HSD17B13 binds lipid droplets (Homo sapiens)

Inferred To

Dmel\CG13833 [cytosol] (Drosophila melanogaster)

hsd17b11 [cytosol] (Xenopus tropicalis)

Homologues of HSD17B13 [cytosol] (Drosophila melanogaster)

Homologues of HSD17B13 [cytosol] (Gallus gallus)

Homologues of HSD17B13 [cytosol] (Xenopus tropicalis)

Dmel\CG17121 [cytosol] (Drosophila melanogaster)

HSD17B11 [cytosol] (Gallus gallus)

HSD17B11 [cytosol] (Saccharomyces cerevisiae)

hsd17b13 [cytosol] (Xenopus tropicalis)

HSD17B13 [cytosol] (Bos taurus)

HSD17B13 [cytosol] (Gallus gallus)

HSD17B13 [cytosol] (Mus musculus)

HSD17B13 [cytosol] (Rattus norvegicus)

HSD17B13 [cytosol] (Sus scrofa)

Homologues of HSD17B11 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_835236.2, NP_001129702.1

Guide to Pharmacology - Targets

3222

OpenTargets

ENSG00000170509

GeneCards

Q7Z5P4

HPA

ENSG00000170509-HSD17B13

Ensembl

ENSG00000170509, ENSP00000333300, ENST00000302219, ENSP00000305438, ENST00000328546

PRO

Q7Z5P4

Pharos - Targets

Q7Z5P4

PDB

8G9V

Interactors (118)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H1Z9 TSN10			0.589	2
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q9NX47 MARH5			0.556	3
UniProt:Q8WV15 T255B			0.556	3
UniProt:Q04941 PLP2			0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:P78329 CYP4F2	1	CYP4F2 [endoplasmic reticulum membrane] (R-HSA-211016)	0.556	3
UniProt:Q9UI14 PRAF1			0.556	3
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.556	3
UniProt:Q8N138 ORMDL3	4	ORMDL3 [specific granule membrane] (R-HSA-6799643) ORMDL3 [plasma membrane] (R-HSA-6806293) ORMDL3 [secretory granule membrane] (R-HSA-6800882) ORMDL3 [endoplasmic reticulum membrane] (R-HSA-8865589)	0.556	3
UniProt:Q96C03-3 MIEF2			0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.556	3
UniProt:Q99726 SLC30A3	1	SLC30A3 [synaptic vesicle membrane] (R-HSA-437087)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q6N075 MFSD5			0.556	3
UniProt:Q6ICL7 S35E4			0.556	3
UniProt:Q9NV12 TM140			0.556	3
UniProt:Q96AG3 S2546			0.556	3
UniProt:Q9NRZ5 AGPAT4	1	AGPAT4 [endoplasmic reticulum membrane] (R-HSA-61809)	0.556	3
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q69YG0 TMM42			0.556	3
UniProt:Q9NVV5-2 AIG1			0.556	3
UniProt:Q9H9B4 SFXN1			0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:Q8IXM6 NRM			0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:Q9BU79 TM243			0.556	3
UniProt:Q06432 CCG1			0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:O15400 STX7			0.556	3
UniProt:Q9Y5U4 INSIG2	1	INSIG2 [endoplasmic reticulum membrane] (R-HSA-1655736)	0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q9BQA9 CYBC1			0.556	3
UniProt:Q5BJF2 SGMR2			0.556	3
UniProt:Q7L5N7 LPCAT2	1	LPCAT2 [endoplasmic reticulum membrane] (R-HSA-1498786)	0.556	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:Q9UHX3 ADGRE2	1	EMR2 [plasma membrane] (R-HSA-444760)	0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:P02787 TF	6	apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) TF [secretory granule lumen] (R-HSA-350704) apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) TF [endoplasmic reticulum lumen] (R-HSA-8956763)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q969F0 FATE1			0.556	3
UniProt:Q9NRX6 KISHB			0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:Q9BWM7 SFXN3			0.556	3
UniProt:Q8NBD8 T229B			0.556	3
UniProt:Q6UX34 SNORC			0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:Q9UGM5 FETUB			0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:A0A0C4DFN3 A0A0C4DFN3			0.556	3
UniProt:Q96HH6 TMM19			0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:P11836 CD20			0.556	3
UniProt:Q9BSR8 YIPF4			0.556	3
UniProt:Q5R3K3 CAHM6			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:P78369 CLDN10	2	CLDN10 [plasma membrane] (R-HSA-420008) CLDN10 [cell junction] (R-HSA-421226)	0.556	3
UniProt:P54315 PNLIPRP1	1	PNLIPRP1 [extracellular region] (R-HSA-3902876)	0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.556	3
UniProt:Q969S6 TM203			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q6PL45-2 BRICD5			0.556	3
UniProt:O00124 UBXN8			0.556	3
UniProt:O75425 MSPD3			0.556	3
UniProt:O14493 CLDN4	2	CLDN4 [plasma membrane] (R-HSA-419987) CLDN4 [cell junction] (R-HSA-421244)	0.556	3
UniProt:P00387 CYB5R3	3	MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217)	0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q9UHE5 NAT8	1	NAT8 [endoplasmic reticulum membrane] (R-HSA-5692986)	0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q6ZUI0 TPRG1			0.556	3
UniProt:O14925 TIMM23	2	TIMM23 [mitochondrial intermembrane space] (R-HSA-1299436) TIMM23 [mitochondrial inner membrane] (R-HSA-1252126)	0.556	3
UniProt:Q8N6F1-2 CLDN19			0.556	3
UniProt:Q16853 AOC3	1	AOC3 [plasma membrane] (R-HSA-5696151)	0.556	3
UniProt:Q9H0R3 TM222			0.556	3
UniProt:Q8TAC9 SCAM5			0.556	3
UniProt:Q9NV29 TM100			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q9P0B6 CC167			0.556	3
UniProt:Q8NHS1 CLDN2			0.556	3
UniProt:P11215 ITGAM	3	ITGAM [specific granule membrane] (R-HSA-6799647) ITGAM [tertiary granule membrane] (R-HSA-6800979) ITGAM [plasma membrane] (R-HSA-202757)	0.556	3
UniProt:Q53HI1 UNC50			0.556	3
UniProt:Q9UPZ6 THSD7A	3	THSD7A [endoplasmic reticulum lumen] (R-HSA-5173009) glc-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173197) O-fuc-THSD7A [endoplasmic reticulum lumen] (R-HSA-5173184)	0.556	3
UniProt:Q96HR9-2 REEP6			0.556	3
UniProt:Q9BXJ8 TACAN			0.556	3
UniProt:Q96NB2 SFXN2			0.556	3
UniProt:Q96JF0-2 ST6GAL2			0.556	3
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:O95237 LRAT	2	LRAT S175R [endoplasmic reticulum membrane] (R-HSA-2466799) LRAT [endoplasmic reticulum membrane] (R-HSA-975606)	0.556	3
UniProt:Q5VYK3 ECM29			0.556	3
UniProt:Q9NSU2-1 TREX1			0.556	3
UniProt:Q9BWQ6 YIPF2			0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.556	3
UniProt:P06028 GYPB	1	GYPB [plasma membrane] (R-HSA-8867209)	0.556	3
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [plasma membrane] (R-HSA-2197636) SCARF1 [endocytic vesicle membrane] (R-HSA-2239453)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:Q9NRZ7 AGPAT3	2	AGPAT3 [Golgi membrane] (R-HSA-8849239) AGPAT3 [endoplasmic reticulum membrane] (R-HSA-61807)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.556	3
UniProt:P50281 MMP14	4	MMP14 [Golgi membrane] (R-HSA-9858808) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472)	0.556	3
UniProt:Q96PG8 BBC3B			0.556	3