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ACVRL1 [plasma membrane]
Stable Identifier
R-HSA-8858382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Serine/threonine-protein kinase receptor R3, ACVL1_HUMAN, ALK1
Locations in the PathwayBrowser for interactor UniProt:P02750 LRG1
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
ACVRL1 binds BMP9,BMP10 (Homo sapiens)
ACVRL1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P37023 ACVRL1
Gene Names
ACVRL1, ACVRLK1, ALK1
Chain
signal peptide:1-21, chain:22-503
Reference Genes
BioGPS Gene:94 ACVRL1
COSMIC (genes):ACVRL1 ACVRL1
CTD Gene:94 ACVRL1
dbSNP Gene:94 ACVRL1
ENSEMBL:ENSG00000139567 ACVRL1
ENSEMBL_homo_sapiens_GENE:ENSG00000139567.13 ACVRL1
HGNC:175 ACVRL1
KEGG Gene (Homo sapiens):94 ACVRL1
Monarch:94 ACVRL1
NCBI Gene:94 ACVRL1
OMIM:601284 ACVRL1
UCSC:P37023 ACVRL1
Reference Transcript
RefSeq:NM_001077401.1 ACVRL1
RefSeq:XM_005269235.2 ACVRL1
RefSeq:NM_000020.2 ACVRL1
Other Identifiers
11721573_a_at
11747260_a_at
16751381
1927_s_at
210838_PM_s_at
210838_s_at
226950_PM_at
226950_at
32714_s_at
3344910
3415111
3415112
3415117
3415118
3415119
3415120
3415122
3415123
3415124
3415126
3415128
3415129
3415131
3415132
3415134
3415135
3415136
3415137
3415139
40594_r_at
44868_s_at
48677_at
7955562
94
A_14_P136394
A_24_P945113
GE60366
GE735413
GO:0000166
GO:0001525
GO:0001666
GO:0001701
GO:0001936
GO:0001937
GO:0001938
GO:0001946
GO:0001955
GO:0001974
GO:0002043
GO:0003013
GO:0003203
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005025
GO:0005515
GO:0005524
GO:0005886
GO:0006260
GO:0006275
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007162
GO:0007165
GO:0007178
GO:0007179
GO:0007507
GO:0008015
GO:0008217
GO:0008285
GO:0009893
GO:0009953
GO:0009986
GO:0010596
GO:0010629
GO:0016020
GO:0016301
GO:0016310
GO:0016361
GO:0016740
GO:0019901
GO:0023052
GO:0030154
GO:0030308
GO:0030336
GO:0030425
GO:0030509
GO:0030513
GO:0030858
GO:0032332
GO:0032924
GO:0034330
GO:0035313
GO:0035912
GO:0036211
GO:0042060
GO:0043025
GO:0043167
GO:0043535
GO:0043537
GO:0045602
GO:0045603
GO:0045747
GO:0045766
GO:0045893
GO:0045944
GO:0046332
GO:0046872
GO:0048185
GO:0048514
GO:0048856
GO:0048870
GO:0050431
GO:0051171
GO:0051239
GO:0051895
GO:0060089
GO:0060255
GO:0060391
GO:0060836
GO:0060840
GO:0060841
GO:0061154
GO:0061298
GO:0070724
GO:0071363
GO:0071560
GO:0071773
GO:0098821
GO:0140096
GO:0141091
GO:1903348
HMNXSV003051515
Hs.8881.0.A1_3p_at
ILMN_1807493
L17075_s_at
PH_hs_0000938
PH_hs_0024822
TC12000410.hg
TC12002362.hg
g425147_3p_a_at
Participates
as a component of
ACVRL1:GDF2 dimer, BMP10 dimer [plasma membrane] (Homo sapiens)
as an input of
ACVRL1 binds BMP9,BMP10 (Homo sapiens)
Inferred To
ACVRL1 [plasma membrane]
(Bos taurus)
ACVRL1 [plasma membrane]
(Canis familiaris)
ACVRL1 [plasma membrane]
(Drosophila melanogaster)
ACVRL1 [plasma membrane]
(Gallus gallus)
ACVRL1 [plasma membrane]
(Mus musculus)
ACVRL1 [plasma membrane]
(Rattus norvegicus)
ACVRL1 [plasma membrane]
(Sus scrofa)
ACVRL1 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000011.2
,
NP_001070869.1
,
XP_005269292.1
ZINC - World Drugs
ACVL1_HUMAN
Guide to Pharmacology - Targets
1784
OpenTargets
ENSG00000139567
ZINC - FDA approved
ACVL1_HUMAN
ZINC - Substances
ACVL1_HUMAN
ZINC - Biogenic
ACVL1_HUMAN
ZINC target
P37023
PRO
P37023
PDB
6SF1
,
6SF3
,
4FAO
,
6SF2
,
3MY0
,
7PPC
,
2LCR
ZINC - Investigational
ACVL1_HUMAN
IntEnz
2.7.11.30
GeneCards
P37023
HPA
ENSG00000139567-ACVRL1
Ensembl
ENSP00000373574
,
ENSG00000139567
,
ENST00000388922
Pharos - Targets
P37023
Orphanet
15079
ZINC - Predictions - Purchasable
ACVL1_HUMAN
HMDB Protein
HMDBP01222
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6P474 PDXD2
0.564
2
UniProt:Q04771 ACVR1
0.527
2
UniProt:Q9UK05-PRO_0000033903 GDF2
0.499
2
UniProt:P02750 LRG1
4
LRG1 [specific granule lumen]
(R-HSA-6799640)
LRG1 [ficolin-1-rich granule lumen]
(R-HSA-6800888)
LRG1 [extracellular region]
(R-HSA-6799675)
LRG1 [tertiary granule lumen]
(R-HSA-6800891)
0.499
3
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