HRASLS transfer acyl group from PC to PE to form NAPE

Stable Identifier
R-HSA-8858298
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRASLS members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains (Golczak et al. 2012), as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines (Mardian et al. 2015). Acyl chain remodelling can play a key role in regulating triglyceride accumulation and energy expenditure in adipocytes, making this process a potential target for treatment of metabolic disorders causing obesity. The example here describes the N-acyltransferase activity of HRASLSs for the production of N-acylphosphatidylethanolamines (NAPEs) (Uyama et al. 2012).

Literature References
PubMed ID Title Journal Year
22825852 Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family

Uyama, T, Ikematsu, N, Inoue, M, Shinohara, N, Jin, XH, Tsuboi, K, Tonai, T, Tokumura, A, Ueda, N

J. Biol. Chem. 2012
26503625 The HRASLS (PLA/AT) subfamily of enzymes

Mardian, EB, Bradley, RM, Duncan, RE

J. Biomed. Sci. 2015
22605381 Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins

Golczak, M, Kiser, PD, Sears, AE, Lodowski, DT, Blaner, WS, Palczewski, K

J. Biol. Chem. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transferase activity, transferring acyl groups of HRASLS [cytosol]
Physical Entity
Activity
Orthologous Events
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