HILPDA binds lipid droplets

Stable Identifier
R-HSA-8858270
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lipid droplet, cytosol
ReviewStatus
5/5
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HILPDA binds lipid droplets
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Hypoxia-inducible lipid droplet-associated protein (HILPDA aka HIG2) was first described as a novel gene inducible by hypoxia and glucose deprivation, but its function and mechanisms of regulation remain unknown. HILPDA is a novel lipid droplet (LD) protein and stimulates intracellular lipid accumulation, which may play an important functional role in diseases associated with pathological lipid accumulation (Gimm et al. 2010, Carr & Ahima 2016).
Literature References
PubMed ID Title Journal Year
20624928 Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1

Amann, K, Schödel, J, Knaup, KX, Hellerbrand, C, Gimm, T, Hackenbeck, T, Teschemacher, B, Warnecke, C, Wiese, M, Eckardt, KU, Deggerich, A, Wiesener, MS, Höning, S

FASEB J. 2010
26515554 Pathophysiology of lipid droplet proteins in liver diseases

Carr, RM, Ahima, RS

Exp. Cell Res. 2016
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Orthologous Events
HILPDA binds lipid droplets (Canis familiaris)
HILPDA binds lipid droplets (Mus musculus)
HILPDA binds lipid droplets (Sus scrofa)
Authored
Jassal, B  (2016-02-18)
Reviewed
D'Eustachio, P  (2016-04-05)
Created
Jassal, B  (2016-02-18)
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