HILPDA binds lipid droplets

Stable Identifier
R-HSA-8858270
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Hypoxia-inducible lipid droplet-associated protein (HILPDA aka HIG2) was first described as a novel gene inducible by hypoxia and glucose deprivation, but its function and mechanisms of regulation remain unknown. HILPDA is a novel lipid droplet (LD) protein and stimulates intracellular lipid accumulation, which may play an important functional role in diseases associated with pathological lipid accumulation (Gimm et al. 2010, Carr & Ahima 2016).

Literature References
PubMed ID Title Journal Year
26515554 Pathophysiology of lipid droplet proteins in liver diseases

Carr, RM, Ahima, RS

Exp. Cell Res. 2016
20624928 Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1

Gimm, T, Wiese, M, Teschemacher, B, Deggerich, A, Schödel, J, Knaup, KX, Hackenbeck, T, Hellerbrand, C, Amann, K, Wiesener, MS, Höning, S, Eckardt, KU, Warnecke, C

FASEB J. 2010
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