Hypoxia-inducible lipid droplet-associated protein (HILPDA aka HIG2) was first described as a novel gene inducible by hypoxia and glucose deprivation, but its function and mechanisms of regulation remain unknown. HILPDA is a novel lipid droplet (LD) protein and stimulates intracellular lipid accumulation, which may play an important functional role in diseases associated with pathological lipid accumulation (Gimm et al. 2010, Carr & Ahima 2016).
Carr, RM, Ahima, RS
Gimm, T, Wiese, M, Teschemacher, B, Deggerich, A, Schödel, J, Knaup, KX, Hackenbeck, T, Hellerbrand, C, Amann, K, Wiesener, MS, Höning, S, Eckardt, KU, Warnecke, C
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