Reactome | Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307

Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307

Stable Identifier

R-HSA-8857925

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307

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SRC family tyrosine kinases, such as SRC and LCK, as well as receptor tyrosine kinases, such as EGFR and insulin receptor, can phosphorylate the catalytic subunit of serine/threonine protein phosphatase PP2A at tyrosine residue Y307. Phosphorylation at Y307 inhibits the catalytic activity of PP2A. Phosphatidylinositol-5-phosphate (PI5P) positively regulates phosphorylation of the catalytic subunit of PP2A at Y307.

Literature References

PubMed ID	Title	Journal	Year
19576174	PtdIns5P protects Akt from dephosphorylation through PP2A inhibition Ramel, D, Lagarrigue, F, Dupuis-Coronas, S, Chicanne, G, Leslie, N, Gaits-Iacovoni, F, Payrastre, B, Tronchère, H	Biochem. Biophys. Res. Commun.	2009
1325671	Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Chen, J, Martin, BL, Brautigan, DL	Science	1992