SRC family tyrosine kinases, such as SRC and LCK, as well as receptor tyrosine kinases, such as EGFR and insulin receptor, can phosphorylate the catalytic subunit of serine/threonine protein phosphatase PP2A at tyrosine residue Y307. Phosphorylation at Y307 inhibits the catalytic activity of PP2A. Phosphatidylinositol-5-phosphate (PI5P) positively regulates phosphorylation of the catalytic subunit of PP2A at Y307.
Ramel, D, Lagarrigue, F, Dupuis-Coronas, S, Chicanne, G, Leslie, N, Gaits-Iacovoni, F, Payrastre, B, Tronchère, H
Chen, J, Martin, BL, Brautigan, DL
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