Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307

Stable Identifier
R-HSA-8857925
Type
Reaction
Species
Homo sapiens
Compartment
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SRC family tyrosine kinases, such as SRC and LCK, as well as receptor tyrosine kinases, such as EGFR and insulin receptor, can phosphorylate the catalytic subunit of serine/threonine protein phosphatase PP2A at tyrosine residue Y307. Phosphorylation at Y307 inhibits the catalytic activity of PP2A. Phosphatidylinositol-5-phosphate (PI5P) positively regulates phosphorylation of the catalytic subunit of PP2A at Y307.

Literature References
PubMed ID Title Journal Year
1325671 Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

Chen, J, Martin, BL, Brautigan, DL

Science 1992
19576174 PtdIns5P protects Akt from dephosphorylation through PP2A inhibition

Leslie, N, Ramel, D, Chicanne, G, Gaits-Iacovoni, F, Lagarrigue, F, Tronchère, H, Payrastre, B, Dupuis-Coronas, S

Biochem. Biophys. Res. Commun. 2009
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Activated SRC,LCK,EGFR,INSR [plasma membrane]

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Orthologous Events
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