SRC family tyrosine kinases, such as SRC and LCK, as well as receptor tyrosine kinases, such as EGFR and insulin receptor, can phosphorylate the catalytic subunit of serine/threonine protein phosphatase PP2A at tyrosine residue Y307. Phosphorylation at Y307 inhibits the catalytic activity of PP2A. Phosphatidylinositol-5-phosphate (PI5P) positively regulates phosphorylation of the catalytic subunit of PP2A at Y307.
Chen, J, Martin, BL, Brautigan, DL
Leslie, N, Ramel, D, Chicanne, G, Gaits-Iacovoni, F, Lagarrigue, F, Tronchère, H, Payrastre, B, Dupuis-Coronas, S
protein tyrosine kinase activity of Activated SRC,LCK,EGFR,INSR [plasma membrane]
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