EGFR phosphorylates GPNMB

Stable Identifier
R-HSA-8857555
Type
Reaction
Species
Homo sapiens
Compartment
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HBEGF-bound EGFR phosphorylates its heterodimerization partner GPNMB at tyrosine residue Y525 (Lin et al. 2016). It is not clear whether trans-autophosphorylation of HBEGF-bound EGFR homodimers precedes heterodimerization of EGFR with GPNBM and GPNMB phosphorylation or if the interaction of GPNMB with the kinase domain of EGFR is sufficient for EGFR kinase activation.

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Marks, JR, Yang, L, Zhou, Y, Ma, G, Wang, S, Xing, Z, Liang, H, Lin, A, Hu, Z, Han, L, Hu, Q, Zhou, Y, Lin, C, Wang, C, Park, PK, Li, C, Zhou, J, Liang, K, Hung, MC, Zhang, Y, Wei, Y, Hawke, DH

Nat. Cell Biol. 2016
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HBEGF:EGFR:GPNMB [plasma membrane]

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