EGFR phosphorylates GPNMB

Stable Identifier
R-HSA-8857555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HBEGF-bound EGFR phosphorylates its heterodimerization partner GPNMB at tyrosine residue Y525 (Lin et al. 2016). It is not clear whether trans-autophosphorylation of HBEGF-bound EGFR homodimers precedes heterodimerization of EGFR with GPNBM and GPNMB phosphorylation or if the interaction of GPNMB with the kinase domain of EGFR is sufficient for EGFR kinase activation.

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Lin, A, Li, C, Xing, Z, Hu, Q, Liang, K, Han, L, Wang, C, Hawke, DH, Wang, S, Zhang, Y, Wei, Y, Ma, G, Park, PK, Zhou, J, Zhou, Y, Hu, Z, Zhou, Y, Marks, JR, Liang, H, Hung, MC, Lin, C, Yang, L

Nat. Cell Biol. 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HBEGF:EGFR:GPNMB [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created