HBEGF-bound EGFR forms a heterodimer with GPNMB

Stable Identifier
R-HSA-8857549
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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EGFR bound to HBEGF (HB-EGF) can form heterodimers with the transmembrane glycoprotein GPNBM. The intracellular domain of GPNMB interacts with the kinase domain of EGFR (Lin et al. 2016).

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Lin, A, Li, C, Xing, Z, Hu, Q, Liang, K, Han, L, Wang, C, Hawke, DH, Wang, S, Zhang, Y, Wei, Y, Ma, G, Park, PK, Zhou, J, Zhou, Y, Hu, Z, Zhou, Y, Marks, JR, Liang, H, Hung, MC, Lin, C, Yang, L

Nat. Cell Biol. 2016
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