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HBEGF:EGFR
Stable Identifier
R-HSA-8857547
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 promotes HIF1A stabilization (Homo sapiens)
EGFR phosphorylates GPNMB (Homo sapiens)
HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
LINC01139 promotes phosphorylation of HIF1A by PTK6 and LRRK2 (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR [plasma membrane] (Homo sapiens)
Participants
components
EGFR [plasma membrane] (Homo sapiens)
HBEGF(63-148) [extracellular region] (Homo sapiens)
Participant Of
input
HBEGF-bound EGFR forms a heterodimer with GPNMB
hasComponent
HBEGF:EGFR:GPNMB [plasma membrane]
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane]
Inferred To
HBEGF:EGFR [plasma membrane] (Bos taurus)
HBEGF:EGFR [plasma membrane] (Canis familiaris)
HBEGF:EGFR [plasma membrane] (Danio rerio)
HBEGF:EGFR [plasma membrane] (Gallus gallus)
HBEGF:EGFR [plasma membrane] (Mus musculus)
HBEGF:EGFR [plasma membrane] (Rattus norvegicus)
HBEGF:EGFR [plasma membrane] (Sus scrofa)
HBEGF:EGFR [plasma membrane] (Taeniopygia guttata)
HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
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