Humans possess three cell death-inducing DFFA-like effector (CIDE) proteins, CIDEA, CIDEB and CIDEC. Initially, their function was determined to be the promotion of apoptosis but they are also known to play a role in energy metabolism. CIDEA and C bind to lipid droplets and regulate their enlargement, thereby restricting lipolysis and favouring storage (by promoting net neutral lipid transfer from smaller to larger lipid droplets) (for review see Gao & Goodman 2015). CIDEA is bound to CIDEC to form a heterodimer (Liu et al. 2009). CIDEB has not been determined to bind lipid droplets.
Zhou, S, Majors, D, Rearick, D, Barricklow, K, Kim, JY, Houston, MS, Fernandez-Boyanapalli, RF, Smas, CM, Liu, K, Lee, JH, Tillison, K
Goodman, JM, Gao, Q
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