Reactome | CIDEA:CIDEC binds lipid droplets

CIDEA:CIDEC binds lipid droplets

Stable Identifier

R-HSA-8856630

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lipid droplet, cytosol

ReviewStatus

5/5

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Humans possess three cell death-inducing DFFA-like effector (CIDE) proteins, CIDEA, CIDEB and CIDEC. Initially, their function was determined to be the promotion of apoptosis but they are also known to play a role in energy metabolism. CIDEA and C bind to lipid droplets and regulate their enlargement, thereby restricting lipolysis and favouring storage (by promoting net neutral lipid transfer from smaller to larger lipid droplets) (for review see Gao & Goodman 2015). CIDEA is bound to CIDEC to form a heterodimer, both subunits of which are required for the adaptor activity annotated here (Liu et al. 2009). CIDEB has not been determined to bind lipid droplets.

Literature References

PubMed ID	Title	Journal	Year
19843876	Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA Liu, K, Zhou, S, Kim, JY, Tillison, K, Majors, D, Rearick, D, Lee, JH, Fernandez-Boyanapalli, RF, Barricklow, K, Houston, MS, Smas, CM	Am. J. Physiol. Endocrinol. Metab.	2009
26322308	The lipid droplet-a well-connected organelle Gao, Q, Goodman, JM	Front Cell Dev Biol	2015