Humans possess three cell death-inducing DFFA-like effector (CIDE) proteins, CIDEA, CIDEB and CIDEC. Initially, their function was determined to be the promotion of apoptosis but they are also known to play a role in energy metabolism. CIDEA and C bind to lipid droplets and regulate their enlargement, thereby restricting lipolysis and favouring storage (by promoting net neutral lipid transfer from smaller to larger lipid droplets) (for review see Gao & Goodman 2015). CIDEA is bound to CIDEC to form a heterodimer (Liu et al. 2009). CIDEB has not been determined to bind lipid droplets.
Gao, Q, Goodman, JM
Liu, K, Zhou, S, Kim, JY, Tillison, K, Majors, D, Rearick, D, Lee, JH, Fernandez-Boyanapalli, RF, Barricklow, K, Houston, MS, Smas, CM
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