Reactome | CIDEA:CIDEC binds lipid droplets

CIDEA:CIDEC binds lipid droplets

Stable Identifier

R-HSA-8856630

Type

Reaction

Species

Homo sapiens

Compartment

lipid droplet, cytosol

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Humans possess three cell death-inducing DFFA-like effector (CIDE) proteins, CIDEA, CIDEB and CIDEC. Initially, their function was determined to be the promotion of apoptosis but they are also known to play a role in energy metabolism. CIDEA and C bind to lipid droplets and regulate their enlargement, thereby restricting lipolysis and favouring storage (by promoting net neutral lipid transfer from smaller to larger lipid droplets) (for review see Gao & Goodman 2015). CIDEA is bound to CIDEC to form a heterodimer (Liu et al. 2009). CIDEB has not been determined to bind lipid droplets.

Literature References

PubMed ID	Title	Journal	Year
26322308	The lipid droplet-a well-connected organelle Gao, Q, Goodman, JM	Front Cell Dev Biol	2015
19843876	Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA Liu, K, Zhou, S, Kim, JY, Tillison, K, Majors, D, Rearick, D, Lee, JH, Fernandez-Boyanapalli, RF, Barricklow, K, Houston, MS, Smas, CM	Am. J. Physiol. Endocrinol. Metab.	2009