CIDEA:CIDEC binds lipid droplets

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Humans possess three cell death-inducing DFFA-like effector (CIDE) proteins, CIDEA, CIDEB and CIDEC. Initially, their function was determined to be the promotion of apoptosis but they are also known to play a role in energy metabolism. CIDEA and C bind to lipid droplets and regulate their enlargement, thereby restricting lipolysis and favouring storage (by promoting net neutral lipid transfer from smaller to larger lipid droplets) (for review see Gao & Goodman 2015). CIDEA is bound to CIDEC to form a heterodimer (Liu et al. 2009). CIDEB has not been determined to bind lipid droplets.

Literature References
PubMed ID Title Journal Year
26322308 The lipid droplet-a well-connected organelle

Gao, Q, Goodman, JM

Front Cell Dev Biol 2015
19843876 Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA

Liu, K, Zhou, S, Kim, JY, Tillison, K, Majors, D, Rearick, D, Lee, JH, Fernandez-Boyanapalli, RF, Barricklow, K, Houston, MS, Smas, CM

Am. J. Physiol. Endocrinol. Metab. 2009
Orthologous Events
Cite Us!