2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors

Stable Identifier
Reaction [binding]
Homo sapiens
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Other RET interactors that may have a role in RET signaling include Mitogen-activated protein kinase 7 (MAPK7, BMK1) (Hayashi et al. 2001), SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) (Schuetz et al. 2004), Insulin receptor substrate-2 (IRS2) (Hennige et al. 2000), SHC-transforming protein 3 (SHC3) (Pelicci et al. 2002), Protein kinase C alpha (PKCA) (Andreozzi et al. 2003) and PDZ and LIM domain protein 7 (Enigma, PDLIM7) (Durick et al. 1996). PDLIM7 and SHANK3 bind Tyrosine-1062 regardless of its phosphorylation state.

Literature References
PubMed ID Title Journal Year
11237712 Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation

Hayashi, Y, Iwashita, T, Murakamai, H, Kato, Y, Kawai, K, Kurokawa, K, Tohnai, I, Ueda, M, Takahashi, M

Biochem. Biophys. Res. Commun. 2001
8662982 Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

Durick, K, Wu, RY, Gill, GN, Taylor, SS

J. Biol. Chem. 1996
14766744 Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival

Encinas, M, Crowder, RJ, Milbrandt, J, Johnson, EM

J. Biol. Chem. 2004
15569713 The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

Schuetz, G, Rosário, M, Grimm, J, Boeckers, TM, Gundelfinger, ED, Birchmeier, W

J. Cell Biol. 2004
11000521 Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells

Hennige, AM, Lammers, R, Arlt, D, Höppner, W, Strack, V, Niederfellner, G, Seif, FJ, Häring, HU, Kellerer, M

Mol. Cell. Endocrinol. 2000
12771945 Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase

Andreozzi, F, Melillo, RM, Carlomagno, F, Oriente, F, Miele, C, Fiory, F, Santopietro, S, Castellone, MD, Beguinot, F, Santoro, M, Formisano, P

Oncogene 2003
12242309 The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway

Pelicci, G, Troglio, F, Bodini, A, Melillo, RM, Pettirossi, V, Coda, L, De Giuseppe, A, Santoro, M, Pelicci, PG

Mol. Cell. Biol. 2002
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