Reactome | KS(2),C6S-ACAN(17-375) [extracellular region]

KS(2),C6S-ACAN(17-375) [extracellular region]

Stable Identifier

R-HSA-8855863

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P16112 ACAN

Gene Names

ACAN, AGC1, CSPG1, MSK16

Chain

signal peptide:1-16, chain:17-2530, chain:393-2530

Reference Genes

BioGPS Gene:176 ACAN

COSMIC (genes):ACAN ACAN

CTD Gene:176 ACAN

dbSNP Gene:176 ACAN

ENSEMBL:ENSG00000157766.19 ACAN

HGNC:319 ACAN

KEGG Gene (Homo sapiens):176 ACAN

Monarch:176 ACAN

NCBI Gene:176 ACAN

OMIM:155760 ACAN

UCSC:P16112 ACAN

Reference Transcript

Other Identifiers

0000070368

0002650026

11725358_a_at

11725359_a_at

16804506

176

205679_PM_x_at

205679_x_at

207692_PM_s_at

207692_s_at

217161_PM_x_at

217161_x_at

3607333

3607334

3607335

3607336

3607337

3607338

3607351

3607352

3607354

3607355

3607356

3607357

3607358

3607359

3607362

3607366

3607368

3607369

3607370

3607371

3607372

3607373

3607374

3607375

3607376

3607377

3607378

3607379

3607380

3607381

3607384

3607385

3607386

3607389

3607393

3607394

3607395

3607396

38965_at

39206_s_at

39207_r_at

7985786

A_14_P133773

A_23_P307310

A_33_P3218741

A_33_P3500167

GE536916

GO:0001501

GO:0005198

GO:0005201

GO:0005515

GO:0005540

GO:0005576

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0005794

GO:0005796

GO:0006508

GO:0007155

GO:0007417

GO:0012505

GO:0030021

GO:0030246

GO:0030312

GO:0031012

GO:0043202

GO:0043226

GO:0046872

GO:0048856

GO:0062023

HMNXSV003038872

ILMN_1686157

ILMN_1693148

ILMN_1699089

ILMN_1740675

ILMN_1777182

M55172_at

PH_hs_0000285

TC15000842.hg

TC15002348.hg

g4501990_3p_a_at

g6995993_3p_x_at

Participates

as a member of

ACAN(17-375) [extracellular region] (Homo sapiens)

Other forms of this molecule

KS(2),C6S-ACAN(393-2415) [extracellular region]

KS(2),CSE-ACAN(393-2415) [extracellular region]

KS(2),C4S-ACAN(393-2415) [extracellular region]

KS(2),CSE-ACAN(17-392) [extracellular region]

KS(2),C4S-ACAN(17-392) [extracellular region]

KS(2),C6S-ACAN(17-392) [extracellular region]

KS(2),C4S-ACAN(376-2415) [extracellular region]

KS(2),CSE-ACAN(376-2415) [extracellular region]

KS(2),C6S-ACAN(376-2415) [extracellular region]

KS(2),C4S-ACAN(17-375) [extracellular region]

KS(2),CSE-ACAN(17-375) [extracellular region]

KS(2),CSE-ACAN(17-360) [extracellular region]

KS(2),C4S-ACAN(17-360) [extracellular region]

KS(2),C6S-ACAN(17-360) [extracellular region]

KS(2),CSE-ACAN(361-2415) [extracellular region]

KS(2),C6S-ACAN(361-2415) [extracellular region]

KS(2),C4S-ACAN(361-2415) [extracellular region]

KS(2),C6S-ACAN [extracellular region]

KS(2),C4S-ACAN [extracellular region]

KS(2),CSE-ACAN [extracellular region]

N-glycan ACAN [Golgi lumen]

Gal-glycan ACAN [Golgi lumen]

Keratan(1)-ACAN [Golgi lumen]

KS(2)-ACAN [extracellular region]

KS(2)-ACAN [lysosomal lumen]

ACAN [lysosomal lumen]

KS(1)-ACAN [Golgi lumen]

KS(2)-ACAN [Golgi lumen]

Keratan(4)-ACAN [Golgi lumen]

Keratan(3)-ACAN [Golgi lumen]

Keratan(2)-ACAN [Golgi lumen]

Inferred To

ACAN [extracellular region] (Bos taurus)

ACAN [extracellular region] (Gallus gallus)

ACAN [extracellular region] (Sus scrofa)

KS(2),C6S-ACAN(17-375) [extracellular region] (Canis familiaris)

KS(2),C6S-ACAN(17-375) [extracellular region] (Danio rerio)

KS(2),C6S-ACAN(17-375) [extracellular region] (Mus musculus)

KS(2),C6S-ACAN(17-375) [extracellular region] (Rattus norvegicus)

kpna7 [extracellular region] (Xenopus tropicalis)

N [extracellular region] (Drosophila melanogaster)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (ChEBI:63520) at unknown position

Modification

alpha-NeuNAc-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal6S-(1->4)-beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-yl group

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Name

O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc6S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position

Modification

beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc6S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group

PsiMod Name

O-xylosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-xylosylserine.

Cross References

RefSeq

XP_011519616.1, NP_001126.3, NP_037359.3

OpenTargets

ENSG00000157766

HPA

ENSG00000157766-ACAN

GeneCards

P16112

Ensembl

ENSP00000341615, ENSP00000387356, ENST00000439576, ENSP00000453499, ENST00000559004, ENST00000352105, ENSG00000157766

PRO

P16112

Pharos - Targets

P16112

Orphanet

15068

HMDB Protein

HMDBP01921

PDB

4MD4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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