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KS(2),C6S-ACAN(17-375) [extracellular region]
Stable Identifier
R-HSA-8855863
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)
ACAN(17-375) [extracellular region] (Homo sapiens)
KS(2),C6S-ACAN(17-375) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16112 ACAN
Gene Names
ACAN, AGC1, CSPG1, MSK16
Chain
signal peptide:1-16, chain:17-2530, chain:393-2530
Reference Genes
BioGPS Gene:176 ACAN
COSMIC (genes):ACAN ACAN
CTD Gene:176 ACAN
dbSNP Gene:176 ACAN
ENSEMBL:ENSG00000157766 ACAN
ENSEMBL_homo_sapiens_GENE:ENSG00000157766 ACAN
HGNC:319 ACAN
KEGG Gene (Homo sapiens):176 ACAN
Monarch:176 ACAN
NCBI Gene:176 ACAN
OMIM:155760 ACAN
UCSC:P16112 ACAN
Reference Transcript
RefSeq:XM_011521314.1 ACAN
RefSeq:NM_013227.3 ACAN
RefSeq:NM_001135.3 ACAN
Other Identifiers
0000070368
0002650026
11725358_a_at
11725359_a_at
16377
16804506
176
205679_x_at
207692_s_at
217161_x_at
3607335
3607336
3607337
3607338
3607351
3607352
3607354
3607355
3607356
3607357
3607358
3607359
3607362
3607366
3607368
3607369
3607370
3607371
3607372
3607373
3607374
3607375
3607376
3607377
3607378
3607379
3607380
3607381
3607384
3607385
3607386
3607389
3607393
3607394
3607395
3607396
38241
38242
38965_at
39206_s_at
39207_r_at
4MD4
7985786
A0A087X1T7
A_14_P133773
A_23_P307310
A_33_P3500167
AAA35726
AAA62824
AAC60643
AAI50625
AC103982
ACAN
ACAN-201
ACAN-202
ACAN-206
ACAN-208
BC150624
CAA35463
CCDS53970
CCDS53971
ENSG00000157766
ENSP00000341615
ENSP00000387356
ENSP00000453342
ENSP00000453499
ENST00000352105
ENST00000439576
ENST00000559004
ENST00000561243
EntrezGene:176
g4501990_3p_a_at
g6995993_3p_x_at
GE536916
GO:0001501
GO:0001502
GO:0002063
GO:0003674
GO:0005198
GO:0005201
GO:0005515
GO:0005540
GO:0005575
GO:0005576
GO:0005604
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0006508
GO:0006790
GO:0007155
GO:0007417
GO:0007507
GO:0008150
GO:0009056
GO:0009058
GO:0018146
GO:0030021
GO:0030154
GO:0030166
GO:0030198
GO:0030199
GO:0030246
GO:0031012
GO:0042340
GO:0043167
GO:0043202
GO:0043226
GO:0044281
GO:0046872
GO:0048856
GO:0062023
H0YMF1
HGNC:319
HPA038241
HPA038242
ILMN_1686157
ILMN_1693148
ILMN_1699089
ILMN_1740675
ILMN_1777182
IPR000436
IPR000538
IPR000742
IPR001304
IPR003006
IPR003599
IPR007110
IPR013032
IPR013106
IPR013783
IPR016186
IPR016187
IPR018378
IPR033987
IPR035976
IPR036179
J05062
M55172
M55172_at
MIM:155760
MIM:165800
MIM:608361
MIM:612813
NM_001135
NM_013227
NP_001126
NP_037359
PF00059
PF00084
PF00193
PF07686
PH_hs_0000285
PR01265
S74659
SM00032
SM00034
SM00181
SM00406
SM00409
SM00445
TC15000842.hg
TC15002348.hg
uc010upo.1
uc010upp.2
uc059myb.1
uc059myc.1
UPI000041D639
UPI0001B23381
UPI0001B23382
X17406
X80278
XM_011521314
XM_017021985
XP_011519616
Participant Of
hasMember
ACAN(17-375) [extracellular region]
Other forms of this molecule
KS(2),C6S-ACAN(393-2415) [extracellular region]
KS(2),CSE-ACAN(393-2415) [extracellular region]
KS(2),C4S-ACAN(393-2415) [extracellular region]
KS(2),CSE-ACAN(17-392) [extracellular region]
KS(2),C4S-ACAN(17-392) [extracellular region]
KS(2),C6S-ACAN(17-392) [extracellular region]
KS(2),C4S-ACAN(376-2415) [extracellular region]
KS(2),CSE-ACAN(376-2415) [extracellular region]
KS(2),C6S-ACAN(376-2415) [extracellular region]
KS(2),C4S-ACAN(17-375) [extracellular region]
KS(2),CSE-ACAN(17-375) [extracellular region]
KS(2),CSE-ACAN(17-360) [extracellular region]
KS(2),C4S-ACAN(17-360) [extracellular region]
KS(2),C6S-ACAN(17-360) [extracellular region]
KS(2),CSE-ACAN(361-2415) [extracellular region]
KS(2),C6S-ACAN(361-2415) [extracellular region]
KS(2),C4S-ACAN(361-2415) [extracellular region]
KS(2),C6S-ACAN [extracellular region]
KS(2),C4S-ACAN [extracellular region]
KS(1)-ACAN [Golgi lumen]
KS(2)-ACAN [Golgi lumen]
Keratan(4)-ACAN [Golgi lumen]
Keratan(3)-ACAN [Golgi lumen]
Keratan(2)-ACAN [Golgi lumen]
Gal-glycan ACAN [Golgi lumen]
Keratan(1)-ACAN [Golgi lumen]
N-glycan ACAN [Golgi lumen]
KS(2)-ACAN [extracellular region]
KS(2)-ACAN [lysosomal lumen]
ACAN [lysosomal lumen]
KS(2),CSE-ACAN [extracellular region]
Inferred To
KS(2),C6S-ACAN(17-375) [extracellular region] (Bos taurus)
KS(2),C6S-ACAN(17-375) [extracellular region] (Canis familiaris)
KS(2),C6S-ACAN(17-375) [extracellular region] (Danio rerio)
KS(2),C6S-ACAN(17-375) [extracellular region] (Gallus gallus)
KS(2),C6S-ACAN(17-375) [extracellular region] (Mus musculus)
KS(2),C6S-ACAN(17-375) [extracellular region] (Rattus norvegicus)
KS(2),C6S-ACAN(17-375) [extracellular region] (Sus scrofa)
KS(2),C6S-ACAN(17-375) [extracellular region] (Taeniopygia guttata)
KS(2),C6S-ACAN(17-375) [extracellular region] (Xenopus tropicalis)
Homologues of KS(2),C6S-ACAN(17-375) [extracellular region] (Bos taurus)
Homologues of KS(2),C6S-ACAN(17-375) [extracellular region] (Canis familiaris)
Homologues of KS(2),C6S-ACAN(17-375) [extracellular region] (Danio rerio)
Homologues of KS(2),C6S-ACAN(17-375) [extracellular region] (Rattus norvegicus)
Homologues of KS(2),C6S-ACAN(17-375) [extracellular region] (Sus scrofa)
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (ChEBI:63520) at unknown position
Modification
alpha-NeuNAc-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal6S-(1->4)-beta-D-GlcNAc6S-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc6S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc6S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_037359.3
,
XP_011519616.1
,
NP_001126.3
OpenTargets
ENSG00000157766
GeneCards
P16112
DOCK Blaster
4MD4
PRO
P16112
Orphanet
15068
PDB
4MD4
HMDB Protein
HMDBP01921
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