Reactome | PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins

PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins

Stable Identifier

R-HSA-8855711

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins

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Asialoglycoprotein receptors 1 and 2 (ASGR1 and ASGR2) mediate the endocytosis of plasma glycoproteins whose terminal sialic acid residues on their complex carbohydrate moieties has been removed. They can bind each other to form at least a heterodimeric complex (Bischoff et al. 1988). The resultant ligand:receptor complex is internalised and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then cycles back to the cell membrane surface. Palmitoylation of ASGR1 (Cys36) and ASGR2 (Cys54, 58) is essential for efficient endocytosis of ligand by the clathrin-dependent endocytic pathway and especially for the proper dissociation and delivery of ligand to lysosomes (Saxena et al. 2002, Yik et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12171918	Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes Saxena, A, Yik, JH, Weigel, PH, Weigel, JA	J. Biol. Chem.	2002
2834401	The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells Lodish, HF, Libresco, S, Bischoff, J, Shia, MA	J. Cell Biol.	1988
12089159	H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid Saxena, A, Yik, JH, Weigel, PH	J. Biol. Chem.	2002