Reactome | APOC1 [extracellular region]

APOC1 [extracellular region]

Stable Identifier

R-HSA-8855541

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Apolipoprotein C-I, APOC1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02654 APOC1

Gene Names

APOC1

Chain

signal peptide:1-26, chain:27-83, chain:29-83

Reference Genes

BioGPS Gene:341 APOC1

COSMIC (genes):APOC1 APOC1

CTD Gene:341 APOC1

dbSNP Gene:341 APOC1

ENSEMBL:ENSG00000130208 APOC1

HGNC:607 APOC1

KEGG:hsa:341 APOC1

Monarch:341 APOC1

NCBI Gene:341 APOC1

OMIM:107710 APOC1

UCSC:P02654 APOC1

Reference Transcript

Other Identifiers

11717986_a_at

11757373_x_at

11763647_at

11763648_x_at

16863124

204416_PM_x_at

204416_x_at

213553_3p_x_at

213553_PM_x_at

213553_x_at

341

3835892

3835893

3835894

3835895

3835896

3835897

3835898

3835899

3835901

3835902

3835903

3835904

41764_at

8029536

89917_at

A_14_P125016

A_23_P4649

A_24_P109214

GE505140

GO:0004859

GO:0005504

GO:0005515

GO:0005576

GO:0005783

GO:0006629

GO:0006641

GO:0006869

GO:0008203

GO:0008289

GO:0010900

GO:0010916

GO:0031210

GO:0032374

GO:0032375

GO:0033344

GO:0033700

GO:0034361

GO:0034364

GO:0034369

GO:0034375

GO:0034379

GO:0034382

GO:0034447

GO:0042157

GO:0042627

GO:0043226

GO:0045717

GO:0045833

GO:0048261

GO:0050995

GO:0051005

GO:0055102

GO:0060228

GO:0065003

GO:0098772

HMNXSV003007962

Hs.268571.1.A1_3p_a_at

ILMN_1789007

M20902_at

PH_hs_0013741

TC19000634.hg

TC19002166.hg

g5174774_3p_a_at

p26743

Participates

as an output of

Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)

as a component of

VLDL [extracellular region] (Homo sapiens)

as an input of

VLDL binds APOC1 and APOC4 (Homo sapiens)

Inferred To

APOC1 [extracellular region] (Canis familiaris)

Apoc1 [extracellular region] (Mus musculus)

Apoc1 [extracellular region] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000130208

ENSEMBL

ENST00000592535, ENST00000588750, ENSP00000468276, ENSP00000468029, ENSP00000465356, ENST00000588802

HPA

ENSG00000130208-APOC1

PRO

P02654

Pharos - Targets

P02654

PDB

6NF3, 6DZ6, 6DXR, 1ALE, 1ALF, 1OPP, 6DVU, 1IOJ

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A8MV81 HIGD1C	1	HIGD1C [mitochondrial inner membrane] (R-HSA-9865734)	0.556	3
UniProt:O00241-2 SIRPB1			0.556	3
IntAct:EBI-23802925 CCSB ORF ID			0.556	3
UniProt:Q5XKP0 MICOS13	1	MIC13 (QIL1) [mitochondrial inner membrane] (R-HSA-8949561)	0.556	3
UniProt:Q8WXG1 RSAD2	1	RSAD2 [endoplasmic reticulum membrane] (R-HSA-5624199)	0.556	3
UniProt:Q9UMS0 NFU1	1	NFU1 [mitochondrial matrix] (R-HSA-1362393)	0.556	3
UniProt:Q6ZUI0 TPRG1			0.556	3
UniProt:Q96QA5 GSDMA			0.556	3
UniProt:Q8N5I4 DHRSX			0.556	3
UniProt:Q8WWC4 C2orf47	1	C2orf47 [mitochondrial inner membrane] (R-HSA-8949660)	0.556	3
UniProt:P56378-2 P563782			0.556	3
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.556	3
UniProt:Q17RD7 SYT16			0.556	3
UniProt:Q96E29 MTERF3	4	Ub-MTERFD1 [mitochondrial outer membrane] (R-HSA-9843333) K48polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-5205630) K63polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-9834044) p-S65-Ub:MTERFD1 [mitochondrial outer membrane] (R-HSA-9843337)	0.556	3
UniProt:Q53QW1 TEX44			0.556	5
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q99525 H4G			0.556	3
UniProt:Q92843 B2CL2			0.556	3
UniProt:Q9UHD4 CIDEB			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:O95563 MPC2	1	MPC2 [mitochondrial inner membrane] (R-HSA-2512891)	0.556	3
UniProt:Q13085-4 ACACA			0.556	3
UniProt:Q6P1Q0 LTMD1			0.556	3
UniProt:Q9Y6C9 MTCH2			0.556	3
UniProt:Q96JH8 RADIL			0.556	3
UniProt:Q6VB84 FX4L3			0.556	3