RELN:VLDLR binds DAB1

Stable Identifier
R-HSA-8855232
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Reelin (RELN) is an extracellular matrix serine protease highly expressed in the brain that plays a role in neural cell positioning during brain development by regulating their microtubule function and neuronal migration. It can bind to the extracellular domains of lipoprotein receptors VLDLR and APOER2 to induce tyrosine phosphorylation of disabled-1 (DAB1), an adaptor protein bound to the cytoplasmic tails of these receptors that is a phosphorylation target for a signaling cascade trigggered by RELN (Bar et al. 2003, for a review see Gao & Godbout 2013).

Literature References
PubMed ID Title Journal Year
12446734 The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse

Bar, I, Tissir, F, Lambert de Rouvroit, C, De Backer, O, Goffinet, AM

J. Biol. Chem. 2003
23052211 Reelin-Disabled-1 signaling in neuronal migration: splicing takes the stage

Gao, Z, Godbout, R

Cell. Mol. Life Sci. 2013
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