Reactome | RELN:VLDLR binds DAB1

RELN:VLDLR binds DAB1

Stable Identifier

R-HSA-8855232

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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Reelin (RELN) is an extracellular matrix serine protease highly expressed in the brain that plays a role in neural cell positioning during brain development by regulating their microtubule function and neuronal migration. It can bind to the extracellular domains of lipoprotein receptors VLDLR and APOER2 to induce tyrosine phosphorylation of disabled-1 (DAB1), an adaptor protein bound to the cytoplasmic tails of these receptors that is a phosphorylation target for a signaling cascade trigggered by RELN (Bar et al. 2003, for a review see Gao & Godbout 2013).

Literature References

PubMed ID	Title	Journal	Year
23052211	Reelin-Disabled-1 signaling in neuronal migration: splicing takes the stage Gao, Z, Godbout, R	Cell. Mol. Life Sci.	2013
12446734	The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse Bar, I, De Backer, O, Lambert de Rouvroit, C, Goffinet, AM, Tissir, F	J. Biol. Chem.	2003