VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane

Stable Identifier
R-HSA-8855130
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Once proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to very low-density lipoprotein receptor (VLDLR), the resultant complex is internalised via the canonical clathrin-dependent endocytic machinery. This degradation route that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve proteasomal or autophagy pathways. The PCSK9:VLDLR:Clathrin-coated vesicle complex translocates from the plasma membrane, via endosomes to the lysosomal membrane where the receptor is degraded (Zhang et al. 2007, Poirier et al. 2008).

Literature References
PubMed ID Title Journal Year
17452316 Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Zhang, DW, Lagace, TA, Garuti, R, Zhao, Z, McDonald, M, Horton, JD, Cohen, JC, Hobbs, HH

J. Biol. Chem. 2007
18039658 The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

Poirier, S, Mayer, G, Benjannet, S, Bergeron, E, Marcinkiewicz, J, Nassoury, N, Mayer, H, Nimpf, J, Prat, A, Seidah, NG

J. Biol. Chem. 2008
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