Reactome | IL22:IL22RA1:JAK1 binds IL10RB:TYK2

IL22:IL22RA1:JAK1 binds IL10RB:TYK2

Stable Identifier

R-HSA-8854645

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

IL10RB:TYK2 receptor complex binds IL22:IL22RA1:JAK1 receptor complex, IL22RA1:IL22 binds IL10RB

ReviewStatus

5/5

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Temporal models suggest that binding of Interleukin‑22 (IL22) to Interleukin‑22 receptor subunit alpha 1 (IL22RA1) creates a surface that is bound by the extracellular region of Interleukin‑10 receptor beta chain (IL10RB) (Li et al. 2004, Bleicher et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
15120653	Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2 Crawford, TK, Wolfman, NM, Heveron, K, Tomkinson, KN, Spaulding, V, Ling, V, Tan, XY, Jacobs, KA, Deng, B, Wright, JF, Pittman, DD, Annis-Freeman, B, Wu, P, Li, J, Veldman, GM, De Zutter, G, Zollner, R, Yan, G, Fouser, LA, Liu, W	Int. Immunopharmacol.	2004