Reactome | APOBR dimer binds VLDLs

APOBR dimer binds VLDLs

Stable Identifier

R-HSA-8854408

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Apolipoprotein B receptor (APOBR dimer) is a dimeric lipid binding receptor on the surface of macrophages. It can bind to and internalise dietary triglyceride-rich lipoproteins (TRLs) and hypertriglyceridemic very low density lipoproteins (HTG-VLDLs), both represented here by VLDL (Gianturco et al. 1998, Brown et al. 2000). APOBR dimer binds to APO-B48 in TRLs or the APO-B48 equivalent domain of APO-B100 in HTG-VLDLs (Bradley et al. 1999). Macrophages can play multifunctional roles in the pathogenesis and progression of atherosclerosis, in which they are important for intracellular lipid accumulation and foam cell formation. Lipid-filled foam cells are seen in atherosclerotic lesions (Brown et al. 2000, Takahashi et al. 2002). PPAR alpha and gamma activators and the blood cholesterol-lowering statin pitavastatin suppress the APOBR pathway in vivo, diminishing APOBR-mediated macrophage lipid accumulation and suggesting an antiatherogenic effect for these suppressors (Haraguchi et al. 2003, Kawakami et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
10191299	Antipeptide antibodies reveal interrelationships of MBP 200 and MBP 235: unique apoB-specific receptors for triglyceride-rich lipoproteins on human monocyte-macrophages Bradley, WA, Brown, ML, Ramprasad, MP, Li, R, Song, R, Gianturco, SH	J. Lipid Res.	1999
12658354	Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals Takahashi, K, Takeya, M, Sakashita, N	Med Electron Microsc	2002
9633939	Apolipoprotein B-48 or its apolipoprotein B-100 equivalent mediates the binding of triglyceride-rich lipoproteins to their unique human monocyte-macrophage receptor Gianturco, SH, Ramprasad, MP, Song, R, Li, R, Brown, ML, Bradley, WA	Arterioscler. Thromb. Vasc. Biol.	1998
10852956	A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis Brown, ML, Ramprasad, MP, Umeda, PK, Tanaka, A, Kobayashi, Y, Watanabe, T, Shimoyamada, H, Kuo, WL, Li, R, Song, R, Bradley, WA, Gianturco, SH	Proc. Natl. Acad. Sci. U.S.A.	2000
15591219	Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism Kawakami, A, Tani, M, Chiba, T, Yui, K, Shinozaki, S, Nakajima, K, Tanaka, A, Shimokado, K, Yoshida, M	Arterioscler. Thromb. Vasc. Biol.	2005
12700342	PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor Haraguchi, G, Kobayashi, Y, Brown, ML, Tanaka, A, Isobe, M, Gianturco, SH, Bradley, WA	J. Lipid Res.	2003