APOBR dimer binds VLDLs

Stable Identifier
R-HSA-8854408
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Apolipoprotein B receptor (APOBR dimer) is a dimeric lipid binding receptor on the surface of macrophages. It can bind to and internalise dietary triglyceride-rich lipoproteins (TRLs) and hypertriglyceridemic very low density lipoproteins (HTG-VLDLs), both represented here by VLDL (Gianturco et al. 1998, Brown et al. 2000). APOBR dimer binds to APO-B48 in TRLs or the APO-B48 equivalent domain of APO-B100 in HTG-VLDLs (Bradley et al. 1999). Macrophages can play multifunctional roles in the pathogenesis and progression of atherosclerosis, in which they are important for intracellular lipid accumulation and foam cell formation. Lipid-filled foam cells are seen in atherosclerotic lesions (Brown et al. 2000, Takahashi et al. 2002). PPAR alpha and gamma activators and the blood cholesterol-lowering statin pitavastatin suppress the APOBR pathway in vivo, diminishing APOBR-mediated macrophage lipid accumulation and suggesting an antiatherogenic effect for these suppressors (Haraguchi et al. 2003, Kawakami et al. 2005).

Literature References
PubMed ID Title Journal Year
12658354 Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

Takahashi, K, Takeya, M, Sakashita, N

Med Electron Microsc 2002
10191299 Antipeptide antibodies reveal interrelationships of MBP 200 and MBP 235: unique apoB-specific receptors for triglyceride-rich lipoproteins on human monocyte-macrophages

Bradley, WA, Brown, ML, Ramprasad, MP, Li, R, Song, R, Gianturco, SH

J. Lipid Res. 1999
9633939 Apolipoprotein B-48 or its apolipoprotein B-100 equivalent mediates the binding of triglyceride-rich lipoproteins to their unique human monocyte-macrophage receptor

Gianturco, SH, Ramprasad, MP, Song, R, Li, R, Brown, ML, Bradley, WA

Arterioscler. Thromb. Vasc. Biol. 1998
10852956 A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis

Brown, ML, Ramprasad, MP, Umeda, PK, Tanaka, A, Kobayashi, Y, Watanabe, T, Shimoyamada, H, Kuo, WL, Li, R, Song, R, Bradley, WA, Gianturco, SH

Proc. Natl. Acad. Sci. U.S.A. 2000
15591219 Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism

Kawakami, A, Tani, M, Chiba, T, Yui, K, Shinozaki, S, Nakajima, K, Tanaka, A, Shimokado, K, Yoshida, M

Arterioscler. Thromb. Vasc. Biol. 2005
12700342 PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor

Haraguchi, G, Kobayashi, Y, Brown, ML, Tanaka, A, Isobe, M, Gianturco, SH, Bradley, WA

J. Lipid Res. 2003
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