Apolipoprotein B receptor (APOBR dimer) is a dimeric lipid binding receptor on the surface of macrophages. It can bind to and internalise dietary triglyceride-rich lipoproteins (TRLs) and hypertriglyceridemic very low density lipoproteins (HTG-VLDLs), both represented here by VLDL (Gianturco et al. 1998, Brown et al. 2000). APOBR dimer binds to APO-B48 in TRLs or the APO-B48 equivalent domain of APO-B100 in HTG-VLDLs (Bradley et al. 1999). Macrophages can play multifunctional roles in the pathogenesis and progression of atherosclerosis, in which they are important for intracellular lipid accumulation and foam cell formation. Lipid-filled foam cells are seen in atherosclerotic lesions (Brown et al. 2000, Takahashi et al. 2002). PPAR alpha and gamma activators and the blood cholesterol-lowering statin pitavastatin suppress the APOBR pathway in vivo, diminishing APOBR-mediated macrophage lipid accumulation and suggesting an antiatherogenic effect for these suppressors (Haraguchi et al. 2003, Kawakami et al. 2005).
Brown, ML, Gianturco, SH, Bradley, WA, Ramprasad, MP, Song, R, Li, R
Sakashita, N, Takahashi, K, Takeya, M
Brown, ML, Umeda, PK, Kuo, WL, Shimoyamada, H, Gianturco, SH, Kobayashi, Y, Bradley, WA, Watanabe, T, Ramprasad, MP, Song, R, Li, R, Tanaka, A
Yui, K, Shimokado, K, Yoshida, M, Chiba, T, Kawakami, A, Tani, M, Nakajima, K, Shinozaki, S, Tanaka, A
Kobayashi, Y, Gianturco, SH, Bradley, WA, Haraguchi, G, Isobe, M, Brown, ML, Tanaka, A
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