Reactome | TBC1D11 binds RAB6

TBC1D11 binds RAB6

Stable Identifier

R-HSA-8854303

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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Rab6 is associated with Golgi and trans-Golgi (TGN) membranes in interphase and regulates a retrograde transport route connecting early endosomes to the endoplasmic reticulum (ER). TBC domain family, member 11 (TBC1D11 also referred as GAPCENA is a Rab GTPase and directly binds Rab6 via its N-terminal PTB domain (Cuif et al. 1999, Miserey-Lenkei et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16395330	A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint Miserey-Lenkei, S, Couëdel-Courteille, A, del Nery, E, Bardin, S, Piel, M, Racine, V, Sibarita, JB, Perez, F, Bornens, M, Goud, B	EMBO J.	2006
10202141	Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome Cuif, MH, Possmayer, F, Zander, H, Bordes, N, Jollivet, F, Couedel-Courteille, A, Janoueix-Lerosey, I, Langsley, G, Bornens, M, Goud, B	EMBO J.	1999