TBC1D10A (EPI64) binds ARF6:GTP

Stable Identifier
R-HSA-8854293
Type
Reaction
Species
Homo sapiens
Compartment
microvillus, recycling endosome membrane
Locations in the PathwayBrowser
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Summation

TBC1D10A (EPI64), a RabGAP protein with a Tre-2/Bub2/Cdc16 (TBC) domain, is an effector of ARF6 and regulates ARF6-dependent membrane trafficking (Hanono et al. 2006). The TBC domain of EPI64 binds to ARF6 and stabilizes ARF6:GTP levels in a manner that is independent of its GAP activity. This interaction keeps ARF6 in an active state either by locking ARF6:GTP in an active state or may sterically hinders ARF6 from associating with its GAP, delaying the hydrolysis of bound GTP to GDP (Hokanson & Bretscher 2011).

Literature References
PubMed ID Title Journal Year
22219378 EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking

Hokanson, DE, Bretscher, AP

Mol. Biol. Cell 2012
Participants
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Participant Of
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Orthologous Events
TBC1D10A (EPI64) binds ARF6:GTP (Bos taurus)
TBC1D10A (EPI64) binds ARF6:GTP (Caenorhabditis elegans)
TBC1D10A (EPI64) binds ARF6:GTP (Canis familiaris)
TBC1D10A (EPI64) binds ARF6:GTP (Danio rerio)
TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)
TBC1D10A (EPI64) binds ARF6:GTP (Gallus gallus)
TBC1D10A (EPI64) binds ARF6:GTP (Mus musculus)
TBC1D10A (EPI64) binds ARF6:GTP (Rattus norvegicus)
TBC1D10A (EPI64) binds ARF6:GTP (Saccharomyces cerevisiae)
TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)
TBC1D10A (EPI64) binds ARF6:GTP (Taeniopygia guttata)
TBC1D10A (EPI64) binds ARF6:GTP (Xenopus tropicalis)
Authored
Garapati, P V  (2016-01-27)