TBC1D20 binds NS5A

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Hepatitis C virus subtype 1a
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TBC (Tre2/Bub2/Cdc16) domain family member 20 (TBC1D20), is a member of the Rab GAP for Rab1, the Rab involved in the regulation of ER-to-Golgi transport. TBC1D20 also interacts with Hepatitis C virus (HCV) nonstructural protein NS5A and this interaction is necessary for efficient HCV infection. It has been proposed that the TBC1D20:NS5A interaction locally inactivates Rab1 at sites of nascent viral protein synthesis to promote redirection from a Golgi-bound pathway to the virus-induced membrane structures, supporting HCV RNA replication (Sklan et al. 2007).

Literature References
PubMed ID Title Journal Year
17901050 TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication

Lambright, DG, Pfeffer, SR, Glenn, JS, Einav, S, Serrano, RL, Sklan, EH

J. Biol. Chem. 2007
Name Identifier Synonyms
hepatitis DOID:2237 acute/subac. necrosis of liver, chronic hepatitis, acute hepatitis, animal hepatitis, acute and subacute liver necrosis, chronic persistent hepatitis
Cite Us!