TBC (Tre2/Bub2/Cdc16) domain family member 20 (TBC1D20), is a member of the Rab GAP for Rab1, the Rab involved in the regulation of ER-to-Golgi transport. TBC1D20 also interacts with Hepatitis C virus (HCV) nonstructural protein NS5A and this interaction is necessary for efficient HCV infection. It has been proposed that the TBC1D20:NS5A interaction locally inactivates Rab1 at sites of nascent viral protein synthesis to promote redirection from a Golgi-bound pathway to the virus-induced membrane structures, supporting HCV RNA replication (Sklan et al. 2007).
Sklan, EH, Serrano, RL, Einav, S, Pfeffer, SR, Lambright, DG, Glenn, JS
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