TBC1D17 binds OPTN:RAB8A

Stable Identifier
R-HSA-8854182
Type
Reaction [binding]
Species
Homo sapiens
Compartment
recycling endosome membrane, recycling endosome
ReviewStatus
5/5
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TBC1D17 binds OPTN:RAB8A
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Rab8 is a small GTPase that is specifically involved in the regulation of secretory/recycling vesicles, modulation of the actin cytoskeleton, and cell polarity. TBC (Tre2/Bub2/Cdc16) domain family member 17 (TAB1CD17), a member of the Rab GTPase-activating protein, regulates Rab8-mediated endocytic trafficking of transferrin receptor through its interaction with optineurin (OPTN) (Vaibhava et al. 2012).
Literature References
PubMed ID Title Journal Year
22854040 Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17

Chalasani, ML, Nagabhushana, A, Kumari, A, Swarup, G, Sudhakar, C, Vaibhava, V

J. Cell. Sci. 2012
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Orthologous Events
TBC1D17 binds OPTN:RAB8A (Bos taurus)
TBC1D17 binds OPTN:RAB8A (Canis familiaris)
TBC1D17 binds OPTN:RAB8A (Drosophila melanogaster)
TBC1D17 binds OPTN:RAB8A (Mus musculus)
TBC1D17 binds OPTN:RAB8A (Rattus norvegicus)
TBC1D17 binds OPTN:RAB8A (Sus scrofa)
TBC1D17 binds OPTN:RAB8A (Xenopus tropicalis)
Authored
Garapati, P V  (2016-01-27)
Created
Garapati, P V  (2016-01-27)
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