VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1

Stable Identifier
R-HSA-8853965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
VENTX binds to TCF4/LEF1 transcription factors at the cyclin D1 (CCND1) promoter and disrupts the interaction of beta-catenin (CTNNB1) with TCF4 and/or LEF1 (Gao et al. 2010).
Literature References
PubMed ID Title Journal Year
20028861 VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor

Le, Y, Silberstein, LE, Giese, RW, Gao, H, Wu, X, Zhu, Z

Cancer Res. 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)
Authored
Orlic-Milacic, M  (2019-06-28)
Reviewed
Vegi, NM  (2019-10-18)
Created
Orlic-Milacic, M  (2016-01-26)
Cite Us!