VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1

Stable Identifier
R-HSA-8853965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1
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VENTX binds to TCF4/LEF1 transcription factors at the cyclin D1 (CCND1) promoter and disrupts the interaction of beta-catenin (CTNNB1) with TCF4 and/or LEF1 (Gao et al. 2010).

Literature References
PubMed ID Title Journal Year
20028861 VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor

Gao, H, Le, Y, Wu, X, Silberstein, LE, Giese, RW, Zhu, Z

Cancer Res. 2010
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Orthologous Events
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Caenorhabditis elegans)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Mus musculus)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2019-06-28)
Reviewed
Vegi, NM  (2019-10-18)
Created
Orlic-Milacic, M  (2016-01-26)
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