Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1

Stable Identifier
R-HSA-8853956
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1
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While the complex of beta-catenin (CTNNB1) and TCF4/LEF1 transcription factors stimulates cyclin D1 (CCND1) transcription, binding of VENTX to TCF4 and/or LEF1 results in the inhibition of CCND1 transcription. VENTX is predominantly expressed in hematopoietic cells and its interaction with TCF4/LEF1 is implicated in the inhibition of cellular proliferation induced by WNT signaling (Gao et al. 2010).
Literature References
PubMed ID Title Journal Year
10318916 The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

Shtutman, M, Albanese, C, D'Amico, M, Zhurinsky, J, Simcha, I, Pestell, R, Ben-Ze'ev, A

Proc. Natl. Acad. Sci. U.S.A. 1999
10201372 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

McCormick, F, Tetsu, O

Nature 1999
20028861 VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor

Le, Y, Silberstein, LE, Giese, RW, Gao, H, Wu, X, Zhu, Z

Cancer Res. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
VENTX [nucleoplasm]
TCF7L2,LEF1 [nucleoplasm]
Positively by
Regulator
CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
CTNNB1:TCF7L2,LEF1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2019-06-28)
Reviewed
Vegi, NM  (2019-10-18)
Created
Orlic-Milacic, M  (2016-01-26)
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