While the complex of beta-catenin (CTNNB1) and TCF4/LEF1 transcription factors stimulates cyclin D1 (CCND1) transcription, binding of VENTX to TCF4 and/or LEF1 results in the inhibition of CCND1 transcription. VENTX is predominantly expressed in hematopoietic cells and its interaction with TCF4/LEF1 is implicated in the inhibition of cellular proliferation induced by WNT signaling (Gao et al. 2010).
Shtutman, M, Albanese, C, D'Amico, M, Zhurinsky, J, Simcha, I, Pestell, R, Ben-Ze'ev, A
McCormick, F, Tetsu, O
Le, Y, Silberstein, LE, Giese, RW, Gao, H, Wu, X, Zhu, Z
© 2022 Reactome