Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1

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Reaction [BlackBoxEvent]
Homo sapiens
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While the complex of beta-catenin (CTNNB1) and TCF4/LEF1 transcription factors stimulates cyclin D1 (CCND1) transcription, binding of VENTX to TCF4 and/or LEF1 results in the inhibition of CCND1 transcription. VENTX is predominantly expressed in hematopoietic cells and its interaction with TCF4/LEF1 is implicated in the inhibition of cellular proliferation induced by WNT signaling (Gao et al. 2010).

Literature References
PubMed ID Title Journal Year
10318916 The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

Shtutman, M, Albanese, C, D'Amico, M, Zhurinsky, J, Simcha, I, Pestell, R, Ben-Ze'ev, A

Proc. Natl. Acad. Sci. U.S.A. 1999
10201372 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

McCormick, F, Tetsu, O

Nature 1999
20028861 VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor

Le, Y, Silberstein, LE, Giese, RW, Gao, H, Wu, X, Zhu, Z

Cancer Res. 2010
This event is regulated
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