VENTX stimulates CSF1R (M-CSF-R) expression

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R-HSA-8853908
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Reaction [omitted]
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Homo sapiens
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Binding of VENTX to the homeobox domain binding (HDB) site in the promoter of the macrophage colony stimulating factor receptor (M-CSFR, CSF1R) gene results in up-regulation of CSF1R transcription. Expression of CSF1R is necessary for differentiation of monocytes into macrophages (Wu et al. 2011).

Literature References
PubMed ID Title Journal Year
21670496 The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

Wu, X, Gao, H, Ke, W, Giese, RW, Zhu, Z

J. Clin. Invest. 2011
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