VENTX stimulates CSF1R (M-CSF-R) expression

Stable Identifier
R-HSA-8853908
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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VENTX stimulates CSF1R (M-CSF-R) expression
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Binding of VENTX to the homeobox domain binding (HDB) site in the promoter of the macrophage colony stimulating factor receptor (M-CSFR, CSF1R) gene results in up-regulation of CSF1R transcription. Expression of CSF1R is necessary for differentiation of monocytes into macrophages (Wu et al. 2011).
Literature References
PubMed ID Title Journal Year
21670496 The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

Giese, RW, Ke, W, Gao, H, Wu, X, Zhu, Z

J. Clin. Invest. 2011
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Regulator
VENTX:CSF1R Gene [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2019-06-28)
Reviewed
Vegi, NM  (2019-10-18)
Created
Orlic-Milacic, M  (2016-01-25)
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