p-5Y-RET complexes bind GRB2

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000), and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). This contrasts with reports in other systems where GAB2-GRB2 were reported to constitutively associate (Gu et al. 1998). The likely order of recruitment to RET is SHC1, GRB2, GAB1/2, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and many others (Adams et al. 2012).

Literature References
PubMed ID Title Journal Year
11002419 Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

Shimono, Y, Murakumo, Y, Kurokawa, K, Murakami, H, Ichihara, M, Takahashi, M, Nakao, A, Kawai, K, Funahashi, H, Hayashi, H, Iwashita, T, Imai, T

Oncogene 2000
10995764 Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase

Scott, RP, Ibáñez, CF, Besset, V

J. Biol. Chem. 2000
Orthologous Events
Cite Us!