GDNF,NRTN bind RET:GFRA1,GFRA2

Stable Identifier
R-HSA-8853789
Type
Reaction [binding]
Species
Homo sapiens
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Glial cell-derived neurotrophic factor (GDNF) (Lin et al. 1993) and neurturin (NRTN) (Kotzbauer et al. 1996) are ligands for GDNF family receptor-alpha (GFRA) 1 and 2 (Jing et al. 1996, 1997, Creedon et al. 1997, Baloh et al. 1997). Despite the cross activation in vitro, GDNF preferentially acts through RET:GFRA1 (Schuchardt et al. 1994, Moore et al. 1996, Pichel et al. 1996, Sanchez et al. 1996, Calcano et al. 1998, Endomoto et al. 1998, whereas NRTN preferentially acts through RET: GFRA2 (Heuckeroth et al. 1999, Rossi et al. 1999, Luo et al. 2004, 2009, Lindfors et al. 2006) in vivo.

Literature References
PubMed ID Title Journal Year
8674117 GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

Jing, S, Wen, D, Yu, Y, Holst, PL, Luo, Y, Fang, M, Tamir, R, Antonio, L, Hu, Z, Cupples, R, Louis, JC, Hu, S, Altrock, BW, Fox, GM

Cell 1996
9407096 GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family

Jing, S, Yu, Y, Fang, M, Hu, Z, Holst, PL, Boone, T, Delaney, J, Schultz, H, Zhou, R, Fox, GM

J. Biol. Chem. 1997
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