Reactome | GDNF,NRTN bind RET:GFRA1,GFRA2

GDNF,NRTN bind RET:GFRA1,GFRA2

Stable Identifier

R-HSA-8853789

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Glial cell-derived neurotrophic factor (GDNF) (Lin et al. 1993) and neurturin (NRTN) (Kotzbauer et al. 1996) are ligands for GDNF family receptor-alpha (GFRA) 1 and 2 (Jing et al. 1996, 1997, Creedon et al. 1997, Baloh et al. 1997). Despite the cross activation in vitro, GDNF preferentially acts through RET:GFRA1 (Schuchardt et al. 1994, Moore et al. 1996, Pichel et al. 1996, Sanchez et al. 1996, Calcano et al. 1998, Endomoto et al. 1998, whereas NRTN preferentially acts through RET: GFRA2 (Heuckeroth et al. 1999, Rossi et al. 1999, Luo et al. 2004, 2009, Lindfors et al. 2006) in vivo.

Literature References

PubMed ID	Title	Journal	Year
8674117	GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF Jing, S, Wen, D, Yu, Y, Holst, PL, Luo, Y, Fang, M, Tamir, R, Antonio, L, Hu, Z, Cupples, R, Louis, JC, Hu, S, Altrock, BW, Fox, GM	Cell	1996
9407096	GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family Jing, S, Yu, Y, Fang, M, Hu, Z, Holst, PL, Boone, T, Delaney, J, Schultz, H, Zhou, R, Fox, GM	J. Biol. Chem.	1997