2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1

Stable Identifier
R-HSA-8853755
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
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2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1
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Phosphorylated RET binds Phospholipase C gamma 1 (PLCG1) via tyrosine 905 (Borello et al. 1996) and/or tyrosine-1015 (Lundgren et al. 2012).

Literature References
PubMed ID Title Journal Year
8628282 The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

Borrello, MG, Alberti, L, Arighi, E, Bongarzone, I, Battistini, C, Bardelli, A, Pasini, B, Piutti, C, Rizzetti, MG, Mondellini, P, Radice, MT, Pierotti, MA

Mol. Cell. Biol. 1996
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Orthologous Events
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Xenopus tropicalis)
Authored
Jupe, S  (2016-01-25)
Reviewed
Morales, D  (2016-05-06)
Luo, W  (2016-05-17)
Created
Jupe, S  (2016-01-25)
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