OTULIN,USP5 cleaves UBC yielding ubiquitin

Stable Identifier
R-HSA-8853515
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The UBC poly-protein contains 9 Ubiquitin monomers that are released by proteolysis. Either USP5 (Falquet et al. 1995) or OTULIN can perform the proteolyic cleavage reactions (Grou et al. 2015).

Literature References
PubMed ID Title Journal Year
7851534 A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro

Falquet, L, Paquet, N, Frutiger, S, Hughes, GJ, Hoang-Van, K, Jaton, JC

FEBS Lett. 1995
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Grou, CP, Pinto, MP, Mendes, AV, Domingues, P, Azevedo, JE

Sci Rep 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of OTULIN,USP5 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created