Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-8853323
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling, as in the WT pathway (reviewed in Parker et al, 2014; Carter et al, 2015).

Literature References
PubMed ID Title Journal Year
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
25467007 Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, EP, Fearon, AE, Grose, RP

Trends Cell Biol. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-Y FGFR3 fusions:p-6Y FRS2:GRB2:GAB1:PI3K [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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