Activated FGFR3 fusions:p-FRS2 binds GRB2:GAB1:PIK3R1

Stable Identifier
R-HSA-8853316
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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FGFR3 fusions have been shown to promote tumorigenesis in part through activation of the AKT pathway suggesting that, as is true for the wild-type pathway, PIK3R1 is recruited to the phosphorylated receptor (reviewed in Parker et al, 2014; Carter et al, 2015).

Literature References
PubMed ID Title Journal Year
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
25467007 Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, EP, Fearon, AE, Grose, RP

Trends Cell Biol. 2015
Participants
Participates
Normal reaction
Functional status

Gain of function of p-Y FGFR3 fusion dimers:p-6Y FRS2 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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