Activated FGFR3 fusions phosphorylate FRS2

Stable Identifier
R-HSA-8853315
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
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Activation of FGFR signaling downstream of FGFR3 fusions likely involves receptor-mediated phosphorylation of FRS2 as in the WT pathway, although this hasn't been conclusively demonstrated in all cases (reviewed in Parker et al, 2014; Carter et al, 2015).

Literature References
PubMed ID Title Journal Year
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
25467007 Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, EP, Fearon, AE, Grose, RP

Trends Cell Biol. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-Y FGFR3 fusions:FRS2 [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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