Activated FGFR3 fusions bind FRS2

Stable Identifier
Reaction [binding]
Homo sapiens
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FGFR3 fusions appear in most cases to promote tumorigenesis and proliferation through the ERK, STAT and AKT pathways suggesting that, as is the case for the wild type receptor, FRS2 is recruited to the phosphorylated receptor (Williams et al, 2013; Parker et al, 2013; Wu et al, 2013; reviewed in Parker et al, 2014; Carter et al, 2015). In contrast, one study reports inhibition of the ERK signaling pathway by FGFR3 fusion proteins. This study supports a model in which the fusion proteins promote chromosomal instability (Singh et al, 2012).

Literature References
PubMed ID Title Journal Year
23175443 Oncogenic FGFR3 gene fusions in bladder cancer

Williams, SV, Hurst, CD, Knowles, MA

Hum. Mol. Genet. 2013
23298836 The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma

Parker, BC, Annala, MJ, Cogdell, DE, Granberg, KJ, Sun, Y, Ji, P, Li, X, Gumin, J, Zheng, H, Hu, L, Yli-Harja, O, Haapasalo, H, Visakorpi, T, Liu, X, Liu, CG, Sawaya, R, Fuller, GN, Chen, K, Lang, FF, Nykter, M, Zhang, W

J. Clin. Invest. 2013
25467007 Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, EP, Fearon, AE, Grose, RP

Trends Cell Biol. 2015
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Normal reaction
Functional status

Gain of function of p-Y FGFR3 fusion dimers [plasma membrane]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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