Activated FGFR3 fusions:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA

Stable Identifier
R-HSA-8853308
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Activation of the AKT pathway has been demonstrated downstream of a number of FGFR fusion mutants and is presumed to occur in a manner analogous to the wild-type receptor (reviewed in Parker et al, 2014; Carter et al, 2015).

Literature References
PubMed ID Title Journal Year
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
25467007 Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

Carter, EP, Fearon, AE, Grose, RP

Trends Cell Biol. 2015
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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