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Clusterin binds C5b-C7, C8, C9
Stable Identifier
R-HSA-8852580
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Clusterin binds C5b-C7, C8, C9 (Homo sapiens)
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Clusterin is a dimer of two fragments of the same translation product, which are disulfide bonded by five cysteines on each peptide (Tobe et al. 1991). It is able to modulate the terminal complement cascade in vitro and prevent cellular lysis by the membrane attack complex (MAC), C5b-9. Clusterin forms complexes with C5b:C6:C7, or C5b:C6:C7:C8 or C5b:C6:C7:C8:C9, as the proteins assemble into the amphiphilic MAC. Clusterin binding renders the complexes soluble and lytically inactive (Jenne & Tschopp 1989, Choi et al. 1989, Murphy et al. 1989, Tschopp et al. 1993).
Literature References
PubMed ID
Title
Journal
Year
8345200
Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9
Chonn, A
,
Hertig, S
,
French, LE
,
Tschopp, J
J. Immunol.
1993
Participants
Input
C5b:C6:C7, C8, C9 [extracellular region]
(Homo sapiens)
CLU [extracellular region]
(Homo sapiens)
Output
CLU:C5b:C6:C7, C8, C9 [extracellular region]
(Homo sapiens)
Participates
as an event of
Regulation of Complement cascade (Homo sapiens)
Orthologous Events
Clusterin binds C5b-C7, C8, C9 (Bos taurus)
Clusterin binds C5b-C7, C8, C9 (Canis familiaris)
Clusterin binds C5b-C7, C8, C9 (Mus musculus)
Clusterin binds C5b-C7, C8, C9 (Rattus norvegicus)
Clusterin binds C5b-C7, C8, C9 (Sus scrofa)
Authored
Jupe, S (2016-01-06)
Reviewed
Bulla, R (2017-02-01)
Created
Jupe, S (2016-01-19)
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